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Reconstructing the history of polar temperature from ice core water isotope (δ¹⁸O) calibration has remained a challenge in paleoclimate research, because of our incomplete understanding of various temperature–δ¹⁸O relationships. This paper resolves this classical problem in a new framework called the unified slope equations (USE), which illustrates the general relations among spatial and temporalδ¹⁸O–surface temperature slopes. The USE is applied to the Antarctica temperature change during the last deglaciation in model simulations and observations. It is shown that the comparable Antarctica-mean spatial slope with deglacial temporal slope inδ¹⁸O–surface temperature reconstruction is caused, accidentally, by the compensation responses between theδ¹⁸O–inversion layer temperature relation and the inversion layer temperature itself. Furthermore, in light of the USE, we propose that the present seasonal slope ofδ¹⁸O–inversion layer temperature is an optimal paleothermometer that is more accurate and robust than the spatial slope. This optimal slope suggests the possibility of reconstructing past Antarctic temperature changes using present and future instrumental observations.

This paper develops a new framework called the unified slope equations (USE) to provide, for the first time, a general relation among various spatial and temporal water isotope–temperature slopes. The application of the USE to Antarctic deglacial temperature change shows that the optimal paleothermometer is the seasonal slope of the inversion layer temperature.

 

Cisplatin, (NH 3 ) 2 PtCl 2 , has been known as a successful metal-based anticancer drug for more than half a century. Its analogue, Argplatin, arginine-linked cisplatin, (Arg)PtCl 2 , is being investigated because it exhibits reactivity towards DNA and RNA that differs from that of cisplatin. In order to understand the basis for its altered reactivity, the deprotonated and sodium cationized forms of Argplatin, [(Arg-H)PtCl 2 ] − and [(Arg)PtCl 2 + Na] + , are examined by infrared multiple photon dissociation (IRMPD) action spectroscopy in the IR fingerprint and hydrogen-stretching regions. Complementary electronic structure calculations are performed using density functional theory approaches to characterize the stable structures of these complexes and to predict their infrared spectra. Comparison of the theoretical IR spectra predicted for various stable conformations of these Argplatin complexes to their measured IRMPD spectra enables determination of the binding mode(s) of Arg to the Pt metal center to be identified. Arginine is found to bind to Pt in a bidentate fashion to the backbone amino nitrogen and carboxylate oxygen atoms in both the [(Arg-H)PtCl 2 ] − and [(Arg)PtCl 2 + Na] + complexes, the NO − binding mode. The neutral side chain of Arg also interacts with the Pt center to achieve additional stabilization in the [(Arg-H)PtCl 2 ] − complex. In contrast, Na + binds to both chlorido ligands in the [(Arg)PtCl 2 + Na] + complex and the protonated side chain of Arg is stabilized via hydrogen-bonding interactions with the carboxylate moiety. These findings are consistent with condensed-phase results, indicating that the NO − binding mode of arginine to Pt is preserved in the electrospray ionization process even under variable pH and ionic strength. 

In order to peak emissions before 2030 and to achieve the net‐zero ambition around 2060, China urgently needs to accelerate low‐carbon transition, especially in the power system. Previous studies were mainly focused on deterministic optimization, with some of them being followed by sensitivity analyses. To tackle the gaps and to support the net‐zero ambition, this study develops a multi‐region power system risk management (MPRM) model to analyze composite effects of renewable energy development and inter‐regional electricity transmission under uncertainties, and their combinations to achieve carbon neutrality by 2060. In detail, MPRM can (a) reveal the downward trend in costs of renewable energy and the increasing in inter‐regional electricity transmission; (b) tackle the uncertainties expressed as intervals; (c) support the low‐carbon transition of the power system. Under the renewable‐dominated power structure, 90% of China's electricity demands can be derived from non‐fossil sources by 2060. Inter‐regional electricity transmission will continue to expand due to the dramatic decreases in the costs of renewables and fast‐growing demands for electricity. Northwest and east regions will be the main exporter and importer of renewable electricity. Carbon emissions from power system will peak in 2030 (about 6.21% above the 2020 level) and be eliminated by 96% (of 2030 levels) by 2060. These results can provide support for expansion of renewable capacities, acceleration of low‐carbon transition in power structure, elimination of barriers in electricity trading across regions, and exploration of the trade‐off between system costs and risk.

 

We investigated the mechanical unfolding of single spectrin molecules over a broad range of loading rates and thus unfolding forces by combining magnetic tweezers with atomic force microscopy. We find that the mean unfolding force increases logarithmically with loading rate at low loading rates, but the increase slows at loading rates above 1pN/s. This behavior indicates an unfolding rate that increases exponentially with the applied force at low forces, as expected on the basis of one-dimensional models of protein unfolding. At higher forces, however, the increase of the unfolding rate with the force becomes faster than exponential, which may indicate anti-Hammond behavior where the structures of the folded and transition states become more different as their free energies become more similar. Such behavior is rarely observed and can be explained by either a change in the unfolding pathway or as a reflection of a multidimensional energy landscape of proteins under force.