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  1. Free, publicly-accessible full text available December 3, 2024
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  4. ABSTRACT

    Modelling galaxy formation in hydrodynamic simulations has increasingly adopted various radiative transfer methods to account for photoionization feedback from young massive stars. However, the evolution of H ii regions around stars begins in dense star-forming clouds and spans large dynamical ranges in both space and time, posing severe challenges for numerical simulations in terms of both spatial and temporal resolution that depends strongly on gas density (∝n−1). In this work, we perform a series of idealized H ii region simulations using the moving-mesh radiation-hydrodynamic code arepo-rt to study the effects of numerical resolution. The simulated results match the analytical solutions and the ionization feedback converges only if the Strömgren sphere is resolved by at least 10–100 resolution elements and the size of each time integration step is smaller than 0.1 times the recombination time-scale. Insufficient spatial resolution leads to reduced ionization fraction but enhanced ionized gas mass and momentum feedback from the H ii regions, as well as degrading the multiphase interstellar medium into a diffuse, partially ionized, warm (∼8000 K) gas. On the other hand, insufficient temporal resolution strongly suppresses the effects of ionizing feedback. This is because longer time-steps are not able to resolve the rapid variation of the thermochemistry properties of the gas cells around massive stars, especially when the photon injection and thermochemistry are performed with different cadences. Finally, we provide novel numerical implementations to overcome the above issues when strict resolution requirements are not achievable in practice.

     
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  5. Free, publicly-accessible full text available July 25, 2024
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  7. Abstract

    Chemical fungicides have been instrumental in protecting crops from fungal diseases. However, increasing fungal resistance to many of the single‐site chemical fungicides calls for the development of new antifungal agents with novel modes of action (MoA). The sequence‐divergent cysteine‐rich antifungal defensins with multisite MoA are promising starting templates for design of novel peptide‐based fungicides. Here, we experimentally tested such a set of 17‐amino‐acid peptides containing the γ‐core motif of the antifungal plant defensin MtDef4. These designed peptides exhibited antifungal properties different from those of MtDef4. Focused analysis of a lead peptide, GMA4CG_V6, showed that it was a random coil in solution with little or no secondary structure elements. Additionally, it exhibited potent cation‐tolerant antifungal activity against the plant fungal pathogenBotrytis cinerea, the causal agent of grey mould disease in fruits and vegetables. Its multisite MoA involved localization predominantly to the plasma membrane, permeabilization of the plasma membrane, rapid internalization into the vacuole and cytoplasm, and affinity for the bioactive phosphoinositides phosphatidylinositol 3‐phosphate (PI3P), PI4P, and PI5P. The sequence motif RRRW was identified as a major determinant of the antifungal activity of this peptide. While topical spray application of GMA4CG_V6 onNicotiana benthamianaand tomato plants provided preventive and curative suppression of grey mould disease symptoms, the peptide was not internalized into plant cells. Our findings open the possibility that truncated and modified defensin‐derived peptides containing the γ‐core sequence could serve as promising candidates for further development of bio‐inspired fungicides.

     
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    Free, publicly-accessible full text available August 1, 2024
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