Search for: All records

Persistent precipitation deficits are among the most impactful consequences of global warming. Here we focus on changes in the annual number of dry days (NDD) and in the annual maximum length of dry spells due to a quadrupling of atmospheric CO₂. We use atmosphere‐only simulations to decompose the projected changes into additive contributions. A fast adjustment leads to a global increase in NDD despite notable regional exceptions (e.g., South Asia and Sahel). The effect of the uniform component of the surface ocean warming is model‐dependent but shapes the regional distribution of the NDD response in each model. Finally, the ocean warming pattern also contributes to large uncertainties, likely through contrasting changes in large‐scale circulation. Our results thus highlight the complexity of the NDD response, with policy‐relevant practical implications for mitigation and adaptation strategies.

 

The analysis of membranous extracellular vesicles, such as exosomes vesicles (EV) opens a new direction for the rapid disease diagnosis because EVs can carry molecular constituents of their originating cells. Secreted by mammalian cells, the size of most membrane-bound phospholipid EVs ranges from 50 to 150 nm in diameter. Recent studies have demonstrated the potential of using EVs for cancer diagnosis and treatment monitoring. To diagnose infectious diseases using EVs, the ability to discriminate EVs from host cells and parasites is key. Here, we report a rapid EV analysis assay that can discriminate EVs based on a host-specific transmembrane protein (CD63 antigen) using a label-free optical biosensor. 

The optical resonances of the silicon nanopost array patterned on a silicon-on-insulator (SOI) substrate have been investigated. The fabricated device supports optical resonances in the range of 1.55 μm with a variable Q factor depending on the angle of incidence. By sealing the device on top of the nanoposts, we demonstrated a lateral flow-through label-free biosensor built on SOI. The biosensor exhibits the refractive index sensitivity of 800 nm/RIU and the femtomolar sensitivity for detection of a breast cancer biomarker (ErbB2). 

A search for pair production of squarks or gluinos decaying via sleptons or weak bosons is reported. The search targets a final state with exactly two leptons with same-sign electric charge or at least three leptons without any charge requirement. The analysed data set corresponds to an integrated luminosity of 139 fb⁻¹of proton-proton collisions collected at a centre-of-mass energy of 13 TeV with the ATLAS detector at the LHC. Multiple signal regions are defined, targeting several SUSY simplified models yielding the desired final states. A single control region is used to constrain the normalisation of theWZ+ jets background. No significant excess of events over the Standard Model expectation is observed. The results are interpreted in the context of several supersymmetric models featuring R-parity conservation or R-parity violation, yielding exclusion limits surpassing those from previous searches. In models considering gluino (squark) pair production, gluino (squark) masses up to 2.2 (1.7) TeV are excluded at 95% confidence level.