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  1. Age related macular degeneration (AMD) is the leading cause of blindness in developed countries. AMD occurs due to dysfunction of the retinal pigment epithelial (RPE) cell basement membrane, the Bruch’s membrane. Previous work in the lab demonstrated that retinal pigment epithelial cells preferred stiff substrates to soft ones, and that RGD-conjugated polyethylene glycol (PEG) hydrogels alone were not sufficient to support long term RPE cell health.​ There is evidence that epithelial and neural cells prefer laminin-derived peptides over fibronectin-derived peptides. Therefore, we examined the fate of RPE cells when seeded on PEG hydrogels conjugated with synthetic laminin peptides. 
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  2. Abstract

    Floods are important disturbances to urban socio‐eco‐technical systems and their meteorological drivers are projected to increase through the century due to global climate change. Urban flood models are numerical models that have the capability of representing the features of urban ecosystems and the mechanisms of flooding that impact them. They have the potential to play a critical role in flood risk assessment, operational response, and resilience planning, but existing models remain limited in their capability to represent integrated flooding processes in urban areas and provide the credible quantitative information needed to support risk assessment and resilience practice. Research to advance model development, facilitate intensive watershed monitoring for model parameterization and validation, and support collaboration between researchers and practitioners should be prioritized. This will represent a substantial, expensive effort, but will still be of great value as cities are faced with urgent challenges posed by climate change in coming decades.

     
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