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  1. Abstract Background

    Native Americans (NAs) are more likely to experience chronic pain than non-Hispanic Whites (NHWs); however, the proximate causes predisposing NAs to chronic pain remain elusive. Likely due to centuries of adversity, discrimination, and marginalization, NAs report greater psychological stress than NHWs, which may place them at risk for sleep problems, a well-established risk factor for chronic pain onset.

    Purpose

    This study examined the effects of psychological stress and sleep problems on subjective and physiological measures of pain processing in NAs and NHWs.

    Methods

    Structural equation modeling was used to determine whether ethnicity (NA or NHW) was associated with psychological stress or sleep problems and whether these variables were related to conditioned pain modulation of pain perception (CPM-pain) and the nociceptive flexion reflex (CPM-NFR), temporal summation of pain (TS-pain) and NFR (TS-NFR), and pain tolerance in a sample of 302 (153 NAs) pain-free participants.

    Results

    NAs experienced more psychological stress (Estimate = 0.027, p = .009) and sleep problems (Estimate = 1.375, p = .015) than NHWs. When controlling for age, sex, physical activity, BMI, and general health, NA ethnicity was no longer related to greater sleep problems. Psychological stress was also related to sleep problems (Estimate = 30.173, p = <.001) and psychological stress promoted sleep problems in NAs (indirect effect = 0.802, p = .014). In turn, sleep problems were associated with greater TS-pain (Estimate = 0.714, p = .004), but not other pain measures.

    Conclusions

    Sleep problems may contribute to chronic pain risk by facilitating pain perception without affecting facilitation of spinal neurons or endogenous inhibition of nociceptive processes. Since psychological stress promoted pain facilitation via enhanced sleep problems, efforts to reduce psychological stress and sleep problems among NAs may improve health outcomes.

     
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  2. Free, publicly-accessible full text available December 1, 2024
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  5. Abstract

    A description is presented of the algorithms used to reconstruct energy deposited in the CMS hadron calorimeter during Run 2 (2015–2018) of the LHC. During Run 2, the characteristic bunch-crossing spacing for proton-proton collisions was 25 ns, which resulted in overlapping signals from adjacent crossings. The energy corresponding to a particular bunch crossing of interest is estimated using the known pulse shapes of energy depositions in the calorimeter, which are measured as functions of both energy and time. A variety of algorithms were developed to mitigate the effects of adjacent bunch crossings on local energy reconstruction in the hadron calorimeter in Run 2, and their performance is compared.

     
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    Free, publicly-accessible full text available November 1, 2024
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  8. Abstract

    A search for decays to invisible particles of Higgs bosons produced in association with a top-antitop quark pair or a vector boson, which both decay to a fully hadronic final state, has been performed using proton-proton collision data collected at$${\sqrt{s}=13\,\text {Te}\hspace{-.08em}\text {V}}$$s=13TeVby the CMS experiment at the LHC, corresponding to an integrated luminosity of 138$$\,\text {fb}^{-1}$$fb-1. The 95% confidence level upper limit set on the branching fraction of the 125$$\,\text {Ge}\hspace{-.08em}\text {V}$$GeVHiggs boson to invisible particles,$${\mathcal {B}({\textrm{H}} \rightarrow \text {inv})}$$B(Hinv), is 0.54 (0.39 expected), assuming standard model production cross sections. The results of this analysis are combined with previous$${\mathcal {B}({\textrm{H}} \rightarrow \text {inv})}$$B(Hinv)searches carried out at$${\sqrt{s}=7}$$s=7, 8, and 13$$\,\text {Te}\hspace{-.08em}\text {V}$$TeVin complementary production modes. The combined upper limit at 95% confidence level on$${\mathcal {B}({\textrm{H}} \rightarrow \text {inv})}$$B(Hinv)is 0.15 (0.08 expected).

     
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    Free, publicly-accessible full text available October 1, 2024