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Efimov trimers are exotic three-body quantum states that emerge from the different types of three-body continua in the vicinity of two-atom Feshbach resonances. In particular, as the strength of the interaction is decreased to a critical point, an Efimov state merges into the atom-dimer threshold and eventually dissociates into an unbound atom-dimer pair. Here we explore the Efimov state in the vicinity of this critical point using coherent few-body spectroscopy in⁷Li atoms using a narrow two-body Feshbach resonance. Contrary to the expectation, we find that the⁷Li Efimov trimer does not immediately dissociate when passing the threshold, and survives as a metastable state embedded in the atom-dimer continuum. We identify this behavior with a universal phenomenon related to the emergence of a repulsive interaction in the atom-dimer channel which reshapes the three-body interactions in any system characterized by a narrow Feshbach resonance. Specifically, our results shed light on the nature of⁷Li Efimov states and provide a path to understand various puzzling phenomena associated with them.

 

Folate supplementation reduces the occurrence of neural tube defects (NTDs), birth defects consisting in the failure of the neural tube to form and close. The mechanisms underlying NTDs and their prevention by folate remain unclear. Here we show that folate receptor 1 (FOLR1) is necessary for the formation of neural tube-like structures in human-cell derived neural organoids. FOLR1 knockdown in neural organoids and inXenopus laevisembryos leads to NTDs that are rescued by pteroate, a folate precursor that is unable to participate in metabolism. We demonstrate that FOLR1 interacts with and opposes the function of CD2-associated protein, molecule essential for apical endocytosis and turnover of C-cadherin in neural plate cells. In addition, folates increase Ca²⁺transient frequency, suggesting that folate and FOLR1 signal intracellularly to regulate neural plate folding. This study identifies a mechanism of action of folate distinct from its vitamin function during neural tube formation.

 

We present multi-epoch spectropolarimetry and spectra for a sample of 14 Type IIn supernovae (SNe IIn). We find that after correcting for likely interstellar polarization, SNe IIn commonly show intrinsic continuum polarization of 1–3 per cent at the time of peak optical luminosity, although a few show weaker or negligible polarization. While some SNe IIn have even stronger polarization at early times, their polarization tends to drop smoothly over several hundred days after peak. We find a tendency for the intrinsic polarization to be stronger at bluer wavelengths, especially at early times. While polarization from an electron scattering region is expected to be grey, scattering of SN light by dusty circumstellar material (CSM) may induce such a wavelength-dependent polarization. For most SNe IIn, changes in polarization degree and wavelength dependence are not accompanied by changes in the position angle, requiring that asymmetric pre-SN mass loss had a persistent geometry. While 2–3 per cent polarization is typical, about 30 per cent of SNe IIn have very low or undetected polarization. Under the simplifying assumption that all SN IIn progenitors have axisymmetric CSM (i.e. disc/torus/bipolar), then the distribution of polarization values we observe is consistent with similarly asymmetric CSM seen from a distribution of random viewing angles. This asymmetry has very important implications for understanding the origin of pre-SN mass loss in SNe IIn, suggesting that it was shaped by binary interaction.

 

Controlling heat flow is a key challenge for applications ranging from thermal management in electronics to energy systems, industrial processing, and thermal therapy. However, progress has generally been limited by slow response times and low tunability in thermal conductance. In this work, we demonstrate an electronically gated solid-state thermal switch using self-assembled molecular junctions to achieve excellent performance at room temperature. In this three-terminal device, heat flow is continuously and reversibly modulated by an electric field through carefully controlled chemical bonding and charge distributions within the molecular interface. The devices have ultrahigh switching speeds above 1 megahertz, have on/off ratios in thermal conductance greater than 1300%, and can be switched more than 1 million times. We anticipate that these advances will generate opportunities in molecular engineering for thermal management systems and thermal circuit design.

 

Abstract SARS-CoV-2 receptor binding domains (RBDs) interact with both the ACE2 receptor and heparan sulfate on the surface of host cells to enhance SARS-CoV-2 infection. We show that suramin, a polysulfated synthetic drug, binds to the ACE2 receptor and heparan sulfate binding sites on the RBDs of wild-type, Delta, and Omicron variants. Specifically, heparan sulfate and suramin had enhanced preferential binding for Omicron RBD, and suramin is most potent against the live SARS-CoV-2 Omicron variant (B.1.1.529) when compared to wild type and Delta (B.1.617.2) variants in vitro. These results suggest that inhibition of live virus infection occurs through dual SARS-CoV-2 targets of S-protein binding and previously reported RNA-dependent RNA polymerase inhibition and offers the possibility for this and other polysulfated molecules to be used as potential therapeutic and prophylactic options against COVID-19. 

How novel phenotypes originate from conserved genes, processes, and tissues remains a major question in biology. Research that sets out to answer this question often focuses on the conserved genes and processes involved, an approach that explicitly excludes the impact of genetic elements that may be classified as clade-specific, even though many of these genes are known to be important for many novel, or clade-restricted, phenotypes. This is especially true for understudied phyla such as mollusks, where limited genomic and functional biology resources for members of this phylum have long hindered assessments of genetic homology and function. To address this gap, we constructed a chromosome-level genome for the gastropodBerghia stephanieae(Valdés, 2005) to investigate the expression of clade-specific genes across both novel and conserved tissue types in this species.

The final assembled and filteredBerghiagenome is comparable to other high-quality mollusk genomes in terms of size (1.05 Gb) and number of predicted genes (24,960 genes) and is highly contiguous. The proportion of upregulated, clade-specific genes varied across tissues, but with no clear trend between the proportion of clade-specific genes and the novelty of the tissue. However, more complex tissue like the brain had the highest total number of upregulated, clade-specific genes, though the ratio of upregulated clade-specific genes to the total number of upregulated genes was low.

Our results, when combined with previous research on the impact of novel genes on phenotypic evolution, highlight the fact that the complexity of the novel tissue or behavior, the type of novelty, and the developmental timing of evolutionary modifications will all influence how novel and conserved genes interact to generate diversity.

 

We present multi-epoch spectropolarimetry of Type IIn supernova SN2017hcc, 16–391 d after explosion. Continuum polarization up to 6 per cent is observed during the first epoch, making SN 2017hcc the most intrinsically polarized SN ever reported at visible wavelengths. During the first 29 d, when the polarization is strongest, the continuum polarization exhibits wavelength dependence that rises toward the blue, then becomes wavelength independent by day 45. The polarization drops rapidly during the first month, even as the flux is still climbing to peak brightness. None the less, unusually high polarization is maintained until day 68, at which point the polarization declines to levels comparable to those of previous well-studied SNe IIn. Only minor changes in position angle (PA) are measured throughout the evolution. The blue slope of the polarized continuum and polarized line emission during the first month suggests that an aspherical distribution of dust grains in pre-shock circumstellar material (CSM) is echoing the SN IIn spectrum and strongly influencing the polarization, while the subsequent decline during the wavelength-independent phase appears consistent with electron scattering near the SN/CSM interface. The persistence of the PA between these two phases suggests that the pre-existing CSM responsible for the dust scattering at early times is part of the same geometric structure as the electron-scattering region that dominates the polarization at later times. SN 2017hcc appears to be yet another, but more extreme, case of aspherical yet well-ordered CSM in Type IIn SNe, possibly resulting from pre-SN mass-loss shaped by a binary progenitor system.