Search for: All records

Hox gene clusters encode transcription factors that drive regional specialization during animal development: e.g. the Hox factor Ubx is expressed in the insect metathoracic (T3) wing appendages and differentiates them from T2 mesothoracic identities. Hox transcriptional regulation requires silencing activities that prevent spurious activation and regulatory crosstalks in the wrong tissues, but this has seldom been studied in insects other than Drosophila, which shows a derived Hox dislocation into two genomic clusters that disjoined Antennapedia (Antp) and Ultrabithorax (Ubx). Here we investigated how Ubx is restricted to the hindwing in butterflies, amidst a contiguous Hox cluster. By analysing Hi-C and ATAC-seq data in the butterfly Junonia coenia, we show that a Topologically Associated Domain (TAD) maintains a hindwing-enriched profile of chromatin opening around Ubx. This TAD is bordered by a Boundary Element (BE) that separates it from a region of joined wing activity around the Antp locus. CRISPR mutational perturbation of this BE releases ectopic Ubx expression in forewings, inducing homeotic clones with hindwing identities. Further mutational interrogation of two non-coding RNA encoding regions and one putative cis-regulatory module within the Ubx TAD cause rare homeotic transformations in both directions, indicating the presence of both activating and repressing chromatin features. We also describe a series of spontaneous forewing homeotic phenotypes obtained in Heliconius butterflies, and discuss their possible mutational basis. By leveraging the extensive wing specialization found in butterflies, our initial exploration of Ubx regulation demonstrates the existence of silencing and insulating sequences that prevent its spurious expression in forewings. 

We present a revised analysis of the photometric reverberation mapping campaign of the narrow-line Seyfert 1 galaxy PKS 0558 − 504 carried out with the Swift Observatory during 2008–2010. Previously, Gliozzi et al. (2013) found using the Discrete Correlation Function (DCF) method that the short-wavelength continuum variations lagged behind variations at longer wavelengths, the opposite of the trend expected for thermal reprocessing of X-rays by the accretion disc, and they interpreted their results as evidence against the reprocessing model. We carried out new DCF measurements that demonstrate that the inverted lag-wavelength relationship found by Gliozzi et al. resulted from their having interchanged the order of the driving and responding light curves when measuring the lags. To determine the inter-band lags and uncertainties more accurately, we carried out new measurements with four independent methods. These give consistent results showing time delays increasing as a function of wavelength, as expected for the disc reprocessing scenario. The slope of the re-analysed delay spectrum appears to be roughly compatible with the predicted τ ∝ λ4/3 relationship for reprocessing by an optically thick and geometrically thin accretion disc, although the data points exhibit a large scatter about the fitted power-law trend.

 

In this paper we present AffordIt!, a tool for adding affordances to the component parts of a virtual object. Following 3D scene reconstruction and segmentation procedures, users find themselves with complete virtual objects, but no intrinsic behaviors have been assigned, forcing them to use unfamiliar Desktop-based 3D editing tools. AffordIt! offers an intuitive solution that allows a user to select a region of interest for the mesh cutter tool, assign an intrinsic behavior and view an animation preview of their work. To evaluate the usability and workload of AffordIt! we ran an exploratory study to gather feedback. In the study we utilize two mesh cutter shapes that select a region of interest and two movement behaviors that a user then assigns to a common household object. The results show high usability with low workload ratings, demonstrating the feasibility of AffordIt! as a valuable 3D authoring tool. Based on these initial results we also present a road-map of future work that will improve the tool in future iterations. 

Analyses of simple models of moist tropical motion systems reveal that the column-mean moist static potential vorticity (MSPV) can explain their propagation and growth. The MSPV is akin to the equivalent PV except it uses moist static energy (MSE) instead of the equivalent potential temperature. Examination of an MSPV budget that is scaled for moist off-equatorial synoptic-scale systems reveals thatα, the ratio between the vertical gradients of latent and dry static energies, describes the relative contribution of dry and moist advective processes to the evolution of MSPV. Horizontal advection of the moist component of MSPV, a process akin to horizontal MSE advection, governs the evolution of synoptic-scale systems in regions of high humidity. On the other hand, horizontal advection of dry PV predominates in a dry atmosphere. Derivation of a “moist static” wave activity density budget reveals thatαalso describes the relative importance of moist and dry processes to wave activity amplification and decay. Linear regression analysis of the MSPV budget in eastern Pacific easterly waves shows that the MSPV anomalies originate over the eastern Caribbean and propagate westward due to dry PV advection. They are amplified by the fluxes of the moist component of MSPV over the Caribbean Sea and over the eastern Pacific from 105° to 130°W, underscoring the importance of moist processes in these waves. On the other hand, dry PV convergence amplifies the waves from 90° to 100°W, likely as a result of the barotropic energy conversions that occur in this region.

 

In this paper, we describe the research and development activities in the Center for Efficient Exascale Discretization within the US Exascale Computing Project, targeting state-of-the-art high-order finite-element algorithms for high-order applications on GPU-accelerated platforms. We discuss the GPU developments in several components of the CEED software stack, including the libCEED, MAGMA, MFEM, libParanumal, and Nek projects. We report performance and capability improvements in several CEED-enabled applications on both NVIDIA and AMD GPU systems. 

We present Fermi Gamma-ray Burst Monitor (Fermi-GBM) and Swift Burst Alert Telescope (Swift-BAT) searches for gamma-ray/X-ray counterparts to gravitational-wave (GW) candidate events identified during the third observing run of the Advanced LIGO and Advanced Virgo detectors. Using Fermi-GBM onboard triggers and subthreshold gamma-ray burst (GRB) candidates found in the Fermi-GBM ground analyses, the Targeted Search and the Untargeted Search, we investigate whether there are any coincident GRBs associated with the GWs. We also search the Swift-BAT rate data around the GW times to determine whether a GRB counterpart is present. No counterparts are found. Using both the Fermi-GBM Targeted Search and the Swift-BAT search, we calculate flux upper limits and present joint upper limits on the gamma-ray luminosity of each GW. Given these limits, we constrain theoretical models for the emission of gamma rays from binary black hole mergers.

 

We search for gravitational-wave (GW) transients associated with fast radio bursts (FRBs) detected by the Canadian Hydrogen Intensity Mapping Experiment Fast Radio Burst Project, during the first part of the third observing run of Advanced LIGO and Advanced Virgo (2019 April 1 15:00 UTC–2019 October 1 15:00 UTC). Triggers from 22 FRBs were analyzed with a search that targets both binary neutron star (BNS) and neutron star–black hole (NSBH) mergers. A targeted search for generic GW transients was conducted on 40 FRBs. We find no significant evidence for a GW association in either search. Given the large uncertainties in the distances of our FRB sample, we are unable to exclude the possibility of a GW association. Assessing the volumetric event rates of both FRB and binary mergers, an association is limited to 15% of the FRB population for BNS mergers or 1% for NSBH mergers. We report 90% confidence lower bounds on the distance to each FRB for a range of GW progenitor models and set upper limits on the energy emitted through GWs for a range of emission scenarios. We find values of order 10⁵¹–10⁵⁷erg for models with central GW frequencies in the range 70–3560 Hz. At the sensitivity of this search, we find these limits to be above the predicted GW emissions for the models considered. We also find no significant coincident detection of GWs with the repeater, FRB 20200120E, which is the closest known extragalactic FRB.

 

Abstract The global network of gravitational-wave observatories now includes five detectors, namely LIGO Hanford, LIGO Livingston, Virgo, KAGRA, and GEO 600. These detectors collected data during their third observing run, O3, composed of three phases: O3a starting in 2019 April and lasting six months, O3b starting in 2019 November and lasting five months, and O3GK starting in 2020 April and lasting two weeks. In this paper we describe these data and various other science products that can be freely accessed through the Gravitational Wave Open Science Center at https://gwosc.org . The main data set, consisting of the gravitational-wave strain time series that contains the astrophysical signals, is released together with supporting data useful for their analysis and documentation, tutorials, as well as analysis software packages.