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Staphylococcus aureus uses small peptides to assess its population densisty ( i.e. , quorum sensing) and regulate virulence at high cell number. Here, we report the design and synthesis of peptidomimetics based on these native signals that strongly block this communication pathway in all four specificity groups of S. aureus .more » « less
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West, Korbin H. ; Shen, Wenqi ; Eisenbraun, Emma L. ; Yang, Tian ; Vasquez, Joseph K. ; Horswill, Alexander R. ; Blackwell, Helen E. ( , ACS Chemical Biology)null (Ed.)
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Vasquez, Joseph K. ; West, Korbin H. ; Yang, Tian ; Polaske, Thomas J. ; Cornilescu, Gabriel ; Tonelli, Marco ; Blackwell, Helen E. ( , Journal of the American Chemical Society)
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Vasquez, Joseph K. ; Blackwell, Helen E. ( , ACS Infectious Diseases)