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In this work we present a framework of designing iterative techniques for image deblurring in inverse problem. The new framework is based on two observations about existing methods. We used Landweber method as the basis to develop and present the new framework but note that the framework is applicable to other iterative techniques. First, we observed that the iterative steps of Landweber method consist of a constant term, which is a low-pass filtered version of the already blurry observation. We proposed a modification to use the observed image directly. Second, we observed that Landweber method uses an estimate of the true image as the starting point. This estimate, however, does not get updated over iterations. We proposed a modification that updates this estimate as the iterative process progresses. We integrated the two modifications into one framework of iteratively deblurring images. Finally, we tested the new method and compared its performance with several existing techniques, including Landweber method, Van Cittert method, GMRES (generalized minimal residual method), and LSQR (least square), to demonstrate its superior performance in image deblurring. 

Pretraining multimodal models on Electronic Health Records (EHRs) provides a means of learning representations that can transfer to downstream tasks with minimal supervision. Recent multimodal models induce soft local alignments between image regions and sentences. This is of particular interest in the medical domain, where alignments might highlight regions in an image relevant to specific phenomena described in free-text. While past work has suggested that attention “heatmaps” can be interpreted in this manner, there has been little evaluation of such alignments. We compare alignments from a state-of-the-art multimodal (image and text) model for EHR with human annotations that link image regions to sentences. Our main finding is that the text has an often weak or unintuitive influence on attention; alignments do not consistently reflect basic anatomical information. Moreover, synthetic modifications — such as substituting “left” for “right” — do not substantially influence highlights. Simple techniques such as allowing the model to opt out of attending to the image and few-shot finetuning show promise in terms of their ability to improve alignments with very little or no supervision. We make our code and checkpoints open-source. 

Electronic Health Records (EHRs) provide vital contextual information to radiologists and other physicians when making a diagnosis. Unfortunately, because a given patient’s record may contain hundreds of notes and reports, identifying relevant information within these in the short time typically allotted to a case is very difficult. We propose and evaluate models that extract relevant text snippets from patient records to provide a rough case summary intended to aid physicians considering one or more diagnoses. This is hard because direct supervision (i.e., physician annotations of snippets relevant to specific diagnoses in medical records) is prohibitively expensive to collect at scale. We propose a distantly supervised strategy in which we use groups of International Classification of Diseases (ICD) codes observed in ‘future’ records as noisy proxies for ‘downstream’ diagnoses. Using this we train a transformer-based neural model to perform extractive summarization conditioned on potential diagnoses. This model defines an attention mechanism that is conditioned on potential diagnoses (queries) provided by the diagnosing physician. We train (via distant supervision) and evaluate variants of this model on EHR data from Brigham and Women’s Hospital in Boston and MIMIC-III (the latter to facilitate reproducibility). Evaluations performed by radiologists demonstrate that these distantly supervised models yield better extractive summaries than do unsupervised approaches. Such models may aid diagnosis by identifying sentences in past patient reports that are clinically relevant to a potential diagnosis. Code is available at https://github.com/dmcinerney/ehr-extraction-models.