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  1. We present a neural interface system-on-chip (NISoC) with 1,024 channels of simultaneous electrical recording and stimulation for high-resolution high-throughput electrophysiology. The 2mm  2mm NISoC in 65nm CMOS integrates a 32  32 array of electrodes vertically coupled to analog front-ends supporting both voltage and current clamping through a programmable interface, ranging over 100dB in voltage and 120dB in current, with 0.82mW power per channel at 5.96mVrms input-referred voltage noise from DC to 12.5kHz signal bandwidth. This includes onchip acquisition with a back-end array of 32 dynamic incremental SAR ADCs for 25Msps 11-ENOB acquisition at 2fJ/level FOM. 
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