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Diverted Total Synthesis of Carolacton-Inspired Analogs Yields Three Distinct Phenotypes in Streptococcus mutans Biofilms

https://doi.org/10.1021/jacs.7b03879

Solinski, Amy E.; Koval, Alexander B.; Brzozowski, Richard S.; Morrison, Kelly R.; Fraboni, Americo J.; Carson, Carrie E.; Eshraghi, Anisa R.; Zhou, Guangfeng; Quivey, Robert G.; Voelz, Vincent A.; et al (May 2017, Journal of the American Chemical Society)

Full Text Available
Twelve-membered macrolactones: privileged scaffolds for the development of new therapeutics

https://doi.org/10.1111/cbdd.12783

Brzozowski, Richard S.; Wuest, William M. (February 2017, Chemical Biology & Drug Design)

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Diverted Total Synthesis of Promysalin Analogs Demonstrates That an Iron-Binding Motif Is Responsible for Its Narrow-Spectrum Antibacterial Activity

https://doi.org/10.1021/jacs.6b03373

Steele, Andrew D.; Keohane, Colleen E.; Knouse, Kyle W.; Rossiter, Sean E.; Williams, Sierra J.; Wuest, William M. (April 2016, Journal of the American Chemical Society)

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The enantioselective synthesis and biological evaluation of chimeric promysalin analogs facilitated by diverted total synthesis

https://doi.org/10.1038/ja.2016.4

Knouse, Kyle W; Wuest, William M (April 2016, The Journal of Antibiotics)

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The Rhizosphere Microbiome: A Playground for Natural Product Chemists

https://doi.org/10.1055/s-0035-1560711

Keohane, Colleen; Steele, Andrew; Wuest, William (December 2015, Synlett)

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Total Synthesis and Biological Investigation of (−)-Promysalin

https://doi.org/10.1021/jacs.5b04767

Steele, Andrew D.; Knouse, Kyle W.; Keohane, Colleen E.; Wuest, William M. (June 2015, Journal of the American Chemical Society)

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