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Aphasizheva, Inna; Alfonzo, Juan; Carnes, Jason; Cestari, Igor; Cruz-Reyes, Jorge; Göringer, H. Ulrich; Hajduk, Stephen; Lukeš, Julius; Madison-Antenucci, Susan; Maslov, Dmitri A.; et al (, Trends in Parasitology)
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Cruz-Reyes, Jorge; Mooers, Blaine HM; Abu-Adas, Zakaria; Kumar, Vikas; Gulati, Shelly (, RNA & DISEASE)Multi-zinc finger proteins are an emerging class of cofactors in DEAH-RHA RNA helicases across highly divergent eukaryotic lineages. DEAH-RHA helicase•zinc finger cofactor partnerships predate the split of kinetoplastid protozoa, which include several human pathogens, from other eukaryotic lineages 100-400 Ma. Despite a long evolutionary history, the prototypical DEAH-RHA domains remain highly conserved. This short review focuses on a recently identified DEAH-RHA helicase•zinc finger cofactor system in kinetoplastid RNA editing, and its potential functional parallels with analogous systems in embryogenesis control in nematodes and antivirus protection in humans.more » « less
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