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Award ID contains: 1659690

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  1. The use of hydrazones as a new type of submonomer in peptoid synthesis is described, giving access to peptoid monomers that are structure-inducing. A wide range of hydrazones were found to readily react with α-bromoamides in routine solid phase peptoid submonomer synthesis. Conditions to promote a one-pot cleavage of the peptoid from the resin and reduction to the corresponding N -alkylamino side chains were also identified, and both the N -imino- and N -alkylamino glycine residues were found to favor the trans -amide bond geometry by NMR, X-ray crystallography, and computational analyses. 
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