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Synthesis and Characterization of Bimetallic Nanoclusters Stabilized by Chiral and Achiral Polyvinylpyrrolidinones. Catalytic C(sp ³ )–H Oxidation

https://doi.org/10.1021/acs.joc.2c00449

Fan, Huafang; Tong, Zongbo; Ren, Zhaoyang; Mishra, Kanchan; Morita, Shunya; Edouarzin, Edruce; Gorla, Lingaraju; Averkiev, Boris; Day, Victor W.; Hua, Duy H. (May 2022, The Journal of Organic Chemistry)

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Synthesis of 1,3,4-Oxadiazoles as Selective T-Type Calcium Channel Inhibitors

https://doi.org/10.3987/COM-19-S(F)5

H. Hua, Duy; Simon Xie, Xinmin; Zhang, Man; Zou, Bende; J. Gunaratna, Medha; Weerasekara, Sahani; Tong, Zongbo; D. T. Nguyen, Thi; Koldas, Serkan; S. Cao, William; et al (January 2020, HETEROCYCLES)

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A One-Pot Intramolecular Tandem Michael–Aldol Annulation Reaction for the Synthesis of Chiral Pentacyclic Terpenes

https://doi.org/10.1055/s-0039-1690521

Lu, Jianyu; Koldas, Serkan; Fan, Huafang; Desper, John; Day, Victor W.; Hua, Duy H. (October 2019, Synthesis)

A chiral tricyclic terpene possessing a 6,6,6-tricyclic framework and a 3,3-dimethyl-7-oxooctylidenyl side chain undergoes a double ring-closing reaction to give two chiral pentacyclic terpenes in a ratio of 4:3 via an intramolecular Michael addition followed by aldol condensation under basic conditions. Three new stereogenic centers are introduced in the initial Michael annulation reaction. Stereoselective installation of an ethoxycarbonyl group at C17 of the two pentacyclic terpenes separately gives the corresponding highly functionalized pentacyclic terpenoids with seven stereogenic centers. The structures and stereochemistry of key intermediates and products are established through X-ray crystallographic analysis. A mechanism is proposed for explaining the stereochemistry in the Michael annulation reaction.
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