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The present study evaluates Mill scale which is a steel industry waste and bismuth trioxide simultaneously as a potential radiation shielding material in geopolymer composite. An innovative and first of its kind lead-free design has been developed for making radiation shielding materials using mill scale and bismuth trioxide as shielding aggregates and industrial wastes such as fly ash and blast furnace slag as precursors for the geopolymer composite. The mill scale and bismuth trioxide based composite material are characterized for their radiation shielding characteristics based on shielding parameters commonly used in radiation shielding like linear attenuation coefficient (μ), half value thickness (HVT) and Mean Free Path (MVP) for 0.662 MeV energy. The determined shielding parameters are compared with traditional shielding materials like concrete with heavy aggregates. X-Ray diffraction studies have confirmed the presence of Bismuth ferrite as the major shielding phase responsible for radiation shielding. The mechanical properties of the prepared composites are determined for their strength in direct compression. Depending upon the radiation shielding parameters like linear attenuation coefficient and half value thickness an optimum dosage of mill scale and bismuth trioxide as a shielding composite to provide adequate shielding for X-Ray diagnostic and medical facilities against X-ray photons of low intensity has been recommended. The highest linear attenuation coefficient values of fly ash and slag based geopolymer composites had been observed to be 0.208 and 0.225, respectively. 

Following traumatic brain injury (TBI), secondary brain damage due to chronic inflammation is the most predominant cause of the delayed onset of mood and memory disorders. Currently no therapeutic approach is available to effectively mitigate secondary brain injury after TBI. One reason is the blood–brain barrier (BBB), which prevents the passage of most therapeutic agents into the brain. Peptides have been among the leading candidates for CNS therapy due to their low immunogenicity and toxicity, bioavailability, and ease of modification. In this study, we demonstrated that non-invasive intranasal (IN) administration of KAFAK, a cell penetrating anti-inflammatory peptide, traversed the BBB in a murine model of diffuse, moderate TBI. Notably, KAFAK treatment reduced the production of proinflammatory cytokines that contribute to secondary injury. Furthermore, behavioral tests showed improved or restored neurological, memory, and locomotor performance after TBI in KAFAK-treated mice. This study demonstrates KAFAK’s ability to cross the blood–brain barrier, to lower proinflammatory cytokines in vivo, and to restore function after a moderate TBI. 

The lack of routine viral genomic surveillance delayed the initial detection of SARS-CoV-2, allowing the virus to spread unfettered at the outset of the U.S. epidemic. Over subsequent months, poor surveillance enabled variants to emerge unnoticed. Against this backdrop, long-standing social and racial inequities have contributed to a greater burden of cases and deaths among minority groups. To begin to address these problems, we developed a new variant surveillance model geared toward building ‘next generation’ genome sequencing capacity at universities in or near rural areas and engaging the participation of their local communities. The resulting genomic surveillance network has generated more than 1,000 SARS-CoV-2 genomes to date, including the first confirmed case in northeast Louisiana of Omicron, and the first and sixth confirmed cases in Georgia of the emergent BA.2.75 and BQ.1.1 variants, respectively. In agreement with other studies, significantly higher viral gene copy numbers were observed in Delta variant samples compared to those from Omicron BA.1 variant infections, and lower copy numbers were seen in asymptomatic infections relative to symptomatic ones. Collectively, the results and outcomes from our collaborative work demonstrate that establishing genomic surveillance capacity at smaller academic institutions in rural areas and fostering relationships between academic teams and local health clinics represent a robust pathway to improve pandemic readiness.