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Sensors that can rapidly assess physiology in the clinic and home environment are poised to revolutionize research and practice in the management of chronic diseases such as heart failure. Ultrawideband (UWB) radar sensors provide a viable and unobtrusive alternative to traditional sensor modalities for physiological sensing. In this paper, we consider the problem of estimation of multilayer tissue profiles using an ultrawideband radar sensor. We pose the joint estimation of the ultrawideband pulse waveform and the multilayer tissue profile as a blind deconvolution problem. We show that constraints on the pulse waveform (bandwidth and time duration) and the structure of tissue range profile (sparsity) can be used to regularize the inversion. We derive both convex and non-convex algorithms for the joint estimation of the pulse waveform and the tissue reflectivity profile and demonstrate the effectiveness of the proposed methods with measured and simulated data experiments.