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Seeking spatiotemporal patterns about how citizens interact with the urban space is critical for understanding how cities function. Such interactions were studied in various forms focusing on patterns of people’s presence, action, and transition in the urban environment, which are defined as human-urban interactions in this paper. Using human activity datasets that utilize mobile positioning technology for tracking the locations and movements of individuals, researchers developed stochastic models to uncover preferential return behaviors and recurrent transitional activity structures in human-urban interactions. Ad-hoc heuristics and spatial clustering methods were applied to derive meaningful activity places in those studies. However, the lack of semantic meaning in the recorded locations makes it difficult to examine the details about how people interact with different activity places. In this study, we utilized geographic context-aware Twitter data to investigate the spatiotemporal patterns of people’s interactions with their activity places in different urban settings. To test consistency of our findings, we used geo-located tweets to derive the activity places in Twitter users’ location histories over three major U.S. metropolitan areas: Greater Boston Area, Chicago, and San Diego, where the geographic context of each location was inferred from its closest land use parcel. The results showed striking spatial and temporal similarities in Twitter users’ interactions with their activity places among the three cities. By using entropy-based predictability measures, this study not only confirmed the preferential return behaviors as people tend to revisit a few highly frequented places but also revealed detailed characteristics of those activity places.