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Natural disasters, such as 2017 hurricanes Irma and María, the 2020 earthquakes in Puerto Rico and the ongoing COVID-19 pandemic, affect students in many aspects including economic, socio-emotional, and academic performance progress. To ensure that students can cope with the aftermath of such searing events, it is necessary to develop initiatives that address these three aspects. Satisfying the financial need is essential, but a long-term solution is mandatory. Hence, providing socio-emotional and academic support and cultivating a sense of purpose are critical to prevent attrition. To secure continued STEM success among students affected by natural disasters, the National Science Foundation has funded several projects at the University of Puerto Rico, a Hispanic Serving Institution. This manuscript presents four NSF-funded projects sharing the common goal of providing support to STEM students to ensure that they succeed despite the said challenges. The first project, titled Nanotechnology Center for Biomedical, Environmental and Sustainability Application, leans heavily on research teams dedicated to design new Nanotechnology platforms to address biomedical and environmental challenges and simultaneously trains a new generation of nanoengineers and nanoscientists throughout the educational echelon starting from public intermediate schools through doctoral programs. The second project, entitled Ecosystem to Expand Capabilities and Opportunitiesmore »