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Evolving artificial metalloenzymes via random mutagenesis

https://doi.org/10.1038/nchem.2927

Yang, Hao ; Swartz, Alan M. ; Park, Hyun June ; Srivastava, Poonam ; Ellis-Guardiola, Ken ; Upp, David M. ; Lee, Gihoon ; Belsare, Ketaki ; Gu, Yifan ; Zhang, Chen ; et al ( January 2018 , Nature Chemistry)

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Artificial Metalloenzymes: Reaction Scope and Optimization Strategies

https://doi.org/10.1021/acs.chemrev.7b00014

Schwizer, Fabian ; Okamoto, Yasunori ; Heinisch, Tillmann ; Gu, Yifan ; Pellizzoni, Michela M. ; Lebrun, Vincent ; Reuter, Raphael ; Köhler, Valentin ; Lewis, Jared C. ; Ward, Thomas R. ( January 2018 , Chemical Reviews)

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Preparation of Artificial Metalloenzymes

Ellis-Guardiola, K. ; Lewis, J. C.* ( January 2018 , Artificial Metalloenzymes and MetalloDNAzymes in Catalysis: From Design to Applications)
Diégues, M. ; Bäckvall, J.-E. ; Pàmies, O. (Ed.)
Transition metal catalysts and enzymes are ubiquitous tools for chemical synthesis. Potential benefits of combining complementary properties of these catalysts have driven efforts to create artificial metalloenzymes (ArMs), hybrid constructs comprised of synthetic metal centers embedded within protein scaffolds. This unique composition necessitates the use of synthetic chemistry, bioconjugation methodology, and protein engineering for ArM formation. Despite this challenge, a range of approaches for ArM formation have been developed. This review provides an overview these different approaches and discussion of potential advantages and disadvantages of each.
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