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Three years ago, addressing racial justice in the United States moved firmly into the mainstream. Following the murder of George Floyd, the ongoing struggle for social justice was again laid bare, and pledges to improve diversity, equity, and inclusion (DEI) began sprouting everywhere. Now, the pendulum is swinging back on these commitments. A backlash against DEI initiatives is rising across all sectors, especially at the state level. Last year’s decision by the US Supreme Court to strike down the consideration of students’ racial status in college admissions has emboldened many who oppose any advancement of DEI. Although there has been specific attention to higher education, other sectors have also been attacked. The retreat includes recent anti-DEI legislation that would affect structures, programs, practices, and curricula that aim to support success for all, including persons who have been historically excluded from or marginalized within science, technology, engineering, mathematics, and medicine (STEMM). Before this backlash worsens, DEI advocates, the scientific community, universities, and federal agencies need to collectively call out the dangers of setting aside DEI and come up with robust ways to demonstrate its value to society.