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Abstract Oxidative phenol coupling reduces reliance on halo/metalated substrates used in conventional redox neutral couplings. A new strategy for constructing polycyclic aromatic hydrocarbons (PAHs) that incorporates oxidative phenol coupling is outlined in a three‐stage approach: oxidative fragment coupling, linking of the two resultant units, and oxidative cyclization. The protocol allows rapid assembly of both planar and helical systems with a high degree of edge functionalization. The incorporation of 12 alkoxy groups on systems with 12 rings gave rise to lower optical gaps compared to systems with a lesser degree of edge functionalization.more » « less
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Pu, Youge; Smaldone, Anthony M; Adrio, Javier; Walsh, Patrick J (, Chemical Science)The synthesis of enantioenriched aziridines is important for drug development due to their prevalence in bioactive molecules. Previous methods often use expensive catalysts, activated substrates, or show poor stereoselectivity. Herein,...more » « lessFree, publicly-accessible full text available September 1, 2026
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Cypher, Sabrine M.; Pauly, Magnus; Castro, Leslie G.; Donley, Carrie L.; Maggard, Paul A.; Goldberg, Karen I. (, ACS Applied Materials & Interfaces)
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