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Abstract Given a smooth projective variety over a number field and an elementof its Brauer group, we consider the specialization of the Brauerclass at a place of good reduction for the variety and the class. Weare interested in the case of K3 surfaces.We show that a Brauer class on a very general polarized K3 surfaceover a number field becomes trivial after specialization at a set ofplaces of positive natural density. We deduce that there exist cubic fourfolds over number fields that are conjecturally irrational, with rational reduction at a positive proportion of places. We also deduce that there are twisted derivedequivalent K3 surfaces which become derived equivalent after reductionat a positive proportion of places.more » « less
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