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Menaquinone Biosynthesis: The Mechanism of 5,8-Dihydroxy-2-naphthoate Synthase (MqnD)

https://doi.org/10.1021/acs.biochem.1c00257

Manion-Sommerhalter, Hannah R.; Fedoseyenko, Dmytro; Joshi, Sumedh; Begley, Tadhg P. (June 2021, Biochemistry)
null (Ed.)
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Menaquinone Biosynthesis: New Strategies to Trap Radical Intermediates in the MqnE-Catalyzed Reaction

https://doi.org/10.1021/acs.biochem.1c00181

Joshi, Sumedh; Fedoseyenko, Dmytro; Sharma, Vishav; Nesbit, Mark A.; Britt, R. David; Begley, Tadhg P. (June 2021, Biochemistry)
null (Ed.)
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Radical SAM Enzyme HydE Generates Adenosylated Fe(I) Intermediates En Route to the [FeFe]-Hydrogenase Catalytic H-Cluster

https://doi.org/10.1021/jacs.0c03802

Tao, Lizhi; Pattenaude, Scott A.; Joshi, Sumedh; Begley, Tadhg P.; Rauchfuss, Thomas B.; Britt, R. David (June 2020, Journal of the American Chemical Society)

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Trapping and Electron Paramagnetic Resonance Characterization of the 5′dAdo ^• Radical in a Radical S -Adenosyl Methionine Enzyme Reaction with a Non-Native Substrate

https://doi.org/10.1021/acscentsci.9b00706

Sayler, Richard I.; Stich, Troy A.; Joshi, Sumedh; Cooper, Nicole; Shaw, Jared T.; Begley, Tadhg P.; Tantillo, Dean J.; Britt, R. David (September 2019, ACS Central Science)

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Menaquinone Biosynthesis: Biochemical and Structural Studies of Chorismate Dehydratase

https://doi.org/10.1021/acs.biochem.9b00105

Mahanta, Nilkamal; Hicks, Katherine A.; Naseem, Saad; Zhang, Yang; Fedoseyenko, Dmytro; Ealick, Steven E.; Begley, Tadhg P. (March 2019, Biochemistry)

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Antibacterial Strategy against H. pylori : Inhibition of the Radical SAM Enzyme MqnE in Menaquinone Biosynthesis

https://doi.org/10.1021/acsmedchemlett.8b00649

Joshi, Sumedh; Fedoseyenko, Dmytro; Mahanta, Nilkamal; Ducati, Rodrigo G.; Feng, Mu; Schramm, Vern L.; Begley, Tadhg P. (November 2018, ACS Medicinal Chemistry Letters)

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