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  7. Ecological research increasingly considers integrative relationships among phenomena at broad spatial and temporal domains. However, such large-scale inferences are commonly confounded by changing properties in the processes that govern phenomena (termed nonstationarity), which can violate assumptions underlying standard analytical methods. Changing conditions are funda-mental and pervasive features in ecology, but their influence on ecological inference and prediction increases with larger spatial and temporal domains for a host of factors. Fortunately, tools for identifying and accommodating potentially confounding spatial or temporal trends are available, and new methods are being rapidly developed. Here, we provide guidance for gaining a better understanding of nonstationarity, its causes, and how it can be addressed. Acknowledging and addressing non-constant trends in ecological patterns and processes is key to conducting large-scale research and effectively translating findings to local policies and practices. 
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