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Abstract Understanding the mechanisms of crustal deformation along convergent margins is critical to identifying seismogenic structures and assessing earthquake hazards for nearby urban centers. In the southern central Andes (28–33$$^{\circ }$$ ${}^{\circ }$S), differences in the style of middle to upper-crustal deformation and associated seismicity are highlighted by the January 19th, 2021 (Mw 6.5) San Juan earthquake. We integrate waveforms recorded at regional and teleseismic distances with co-seismic displacements calculated from local Global Navigation Satellite System time series, to re-estimate the source parameters of the 2021 San Juan earthquake, confirming a mid-crustal nucleation depth (21 ± 2 km) and right-lateral transpressional mechanism. Considered alongside decades of seismic observations and geological data, this event provides evidence for retroarc deformation partitioning among inherited basement faults and upper-crustal structures in response to oblique convergence of the Nazca and South American plates. As they may transfer shortening to active upper-crustal faults associated with historically devastating shallower earthquakes, a better understanding of seismogenic basement faults such as the mid-crustal structure activated during the 2021 San Juan earthquake earthquake could help future re-assessment of the seismic risk in western Argentina. 

Abstract The Andes of western Argentina record spatiotemporal variations in morphology, basin geometry, and structural style that correspond with changes in crustal inheritance and convergent margin dynamics. Above the modern Pampean flat‐slab subduction segment (27–33°S), retroarc shortening generated a fold‐thrust belt and intraforeland basement uplifts that converge north of ∼29°S, providing opportunities to explore the effects of varied deformation and subduction regimes on synorogenic sedimentation. We integrate new detrital zircon U‐Pb and apatite (U‐Th)/He analyses with sequentially restored, flexurally balanced cross sections and thermokinematic models at ∼28.5–30°S to link deformation with resulting uplift, erosion, and basin accumulation histories. Tectonic subsidence, topographic evolution, and thermochronometric cooling records point to (a) shortening and distal foreland basin accumulation at ∼18–16 Ma, (b) thrust belt migration, changes in sediment provenance, and enhanced flexural subsidence from ∼16 to 9 Ma, (c) intraforeland basement deformation, local flexure, and drainage reorganization at ∼12–7 Ma, and (d) out‐of‐sequence shortening and exhumation of foreland basin fill by ∼8–2 Ma. Thrust belt kinematics and the reactivation of basement heterogeneities strongly controlled tectonic load configurations and subsidence patterns. Geo/thermochronological data and model results resolve increased shortening and combined thrust belt and intraforeland basement loading in response to ridge collision and Neogene shallowing of the subducted oceanic slab. Finally, this study demonstrates the utility of integrated flexural thermokinematic and erosion modeling for evaluating the geometries, rates, and potential drivers of retroarc deformation and foreland basin evolution during changes in subduction.