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Abstract This case study describes an experimental initiative at James Madison University funded by a National Science Foundation grant in Fall 2021 that aimed to support interdisciplinary collaborative pedagogical development related to Science, Technology, and Society (STS) with a particular focus on ethics and justice. The case study argues that creating infrastructure to cultivate and sustain small teaching communities of practice that include faculty from humanities, social sciences, and STEM fields, can support the challenging and necessary work of developing integrated STS-informed pedagogies across the curriculum. A flexible framework is examined through multiple lenses, including perspectives from each faculty participant, representing teaching departments of Biology, World Languages & Cultures, Integrated Science and Technology/Biotechnology, Justice Studies/Disability Studies, and Integrated Science and Technology/Public Interest Technology and Science. Authors provide key insights about what enables and sustains an interdisciplinary community of practice.