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Since the start of the COVID-19 pandemic, disruptions have been experienced in many supply chains, particularly in personal protective equipment, testing kits, and even essential household goods. Effective vaccines to protect against COVID-19 were approved for emergency use in the United States in late 2020, which led to one of the most extensive vaccination campaigns in history. We continuously collect data on vaccine allocation, shipment and distribution, administration, and inventory in the United States, covering the entire vaccination campaign. In this article, we describe some data sets that we collaborated to obtain. We are publishing the data and making them freely available to researchers, media organizations, and other stakeholders so that others may use the data to develop insights about the distribution and wastage of vaccines during the current pandemic or to provide an informed future pandemic response. This article gives an overview of vaccine distribution logistics in the United States, describes the data we obtain, outlines how they may be accessed and used by others, and describes some high-level analyses demonstrating some aspects of the data (for data collected during January 1, 2021–March 31, 2021). This article also provides directions for future research using the collected data. Our goal is two-fold: (i) We would like the data to be used in many creative ways to inform the current and future pandemic response. (ii) We also want to inspire other researchers to make their data publicly available in a timely manner.