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Not AvaIn this study, a novel near-infrared (NIR) ICG-based J-aggregate contrast agent was used for photoacoustic tomography (PAT) to image whole organs in a nude mouse model. NIR-PAT obtained at the 895-nm absorption peak of our nanoparticles, we were able to resolve organs of interest that included the liver and kidney along with vasculature deeper into biological tissue while maintaining fine spatial resolution. NIR-PAT shows promising applications in small-animal functional imaging, including measuring oxygen saturation levels and studying biodistribution of contrast agents, leading to potential clinical imaging studies for drug development and delivery, and angiographic studies.ilable 

only short abstract available on SPIE website; but the video of the presentation is available 

Fluorescence and photoacoustic imaging techniques offer valuable insights into cell- and tissue-level processes. However, these optical imaging modalities are limited by scattering and absorption in tissue, resulting in the low-depth penetration of imaging. Contrast-enhanced imaging in the near-infrared window improves imaging penetration by taking advantage of reduced autofluorescence and scattering effects. Current contrast agents for fluorescence and photoacoustic imaging face several limitations from photostability and targeting specificity, highlighting the need for a novel imaging probe development. This review covers a broad range of near-infrared fluorescent and photoacoustic contrast agents, including organic dyes, polymers, and metallic nanostructures, focusing on their optical properties and applications in cellular and animal imaging. Similarly, we explore encapsulation and functionalization technologies toward building targeted, nanoscale imaging probes. Bioimaging applications such as angiography, tumor imaging, and the tracking of specific cell types are discussed. This review sheds light on recent advancements in fluorescent and photoacoustic nanoprobes in the near-infrared window. It serves as a valuable resource for researchers working in fields of biomedical imaging and nanotechnology, facilitating the development of innovative nanoprobes for improved diagnostic approaches in preclinical healthcare.