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Expanding tricoordinate Au(I) complexes for efficient carbofunctionalization of alkynes to benzo-fused N-heterocycles and imines

https://doi.org/10.1016/j.jcat.2025.116317

Akrofi-Mantey, Harold; Greif, Charles E; Odagwe, Ugochukwu B; Awuah, Samuel G (October 2025, Journal of Catalysis)

Gold-catalyzed activation of alkynes towards functional molecules remains an interesting endeavor with industrial potential, yet stable, efficient catalysts are needed. Here, we report a shelf-stable tricoordinate Au(I) catalyst for the cyclization of anilino-alkyne derivatives to form C2-substituted indoles and other benzo-fused Nheterocycles. We also report the use of this Au(I) catalyst for intermolecular hydroamination of ethynylbenzene and diphenylacetylene with various aniline derivatives, forming imines. The distorted geometry of Au(I) complexes facilitates alkyne activation and demonstrates functional group tolerance of the catalyst under mild conditions. We expand the scope of previously synthesized benzo-fused N-heterocycles and demonstrate potential for tricoordinate complexes in catalytic systems.
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Free, publicly-accessible full text available October 1, 2026
Discovery of a Pyrazolopyridinone-Based MYC Inhibitor That Selectively Engages Intracellular c-MYC and Disrupts MYC–MAX Heterodimerization

https://doi.org/10.1021/acs.jmedchem.4c02556

Obisesan, Oluwatosin A; Ofori, Samuel; Orobator, Owamagbe N; Sharma, Himanshi; Groetecke, Emma; Awuah, Samuel G (March 2025, Journal of Medicinal Chemistry)

Free, publicly-accessible full text available March 27, 2026
Functional utility of gold complexes with phosphorus donor ligands in biological systems

https://doi.org/10.1016/j.ccr.2024.216208

Arojojoye, Adedamola S; Awuah, Samuel G (January 2025, Coordination Chemistry Reviews)

Free, publicly-accessible full text available January 1, 2026
Metal-Mediated Ligand Affinity Chemistry (MLAC)

https://doi.org/10.1007/978-1-0716-3469-1_6

Gukathasan, Sailajah; Awuah, Samuel G (September 2023, Springer US)

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Circumventing Physicochemical Barriers of Cyclometalated Gold(III) Dithiocarbamate Complexes with Protein-Based Nanoparticle Delivery to Enhance Anticancer Activity

https://doi.org/10.1021/acsami.3c10025

Arojojoye, Adedamola S; Walker, Breyanna; Dawahare, James C; Afrifa, Maame_Abena O; Parkin, Sean; Awuah, Samuel G (September 2023, ACS Applied Materials & Interfaces)

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A Conformationally Restricted Gold(III) Complex Elicits Antiproliferative Activity in Cancer Cells

https://doi.org/10.1021/acs.inorgchem.3c02066

Gukathasan, Sailajah; Obisesan, Oluwatosin A; Saryazdi, Setareh; Ratliff, Libby; Parkin, Sean; Grossman, Robert B; Awuah, Samuel G (August 2023, Inorganic Chemistry)

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Next Generation Gold Drugs and Probes: Chemistry and Biomedical Applications

https://doi.org/10.1021/acs.chemrev.2c00649

Mertens, R. Tyler; Gukathasan, Sailajah; Arojojoye, Adedamola S.; Olelewe, Chibuzor; Awuah, Samuel G. (May 2023, Chemical Reviews)

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