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Organogenesis involves large deformations and complex shape changes that require elaborate mechanical regulation. Models of tissue biomechanics have been introduced to account for the coupling between mechanical response and biochemical processes. Recent experimental evidence indicates that the mechanical response of epithelial tissue is strongly anisotropic, with the degree of anisotropy being correlated with the existence of long-range orientational order of cytoskeletal organization across the tissue. A theoretical framework is introduced that captures the dynamic feedback between tissue elastic response and cytoskeletal reorganization under stress. Within the linear regime for small and uniform applied strains, the shear modulus is effectively reduced by the nematic order in cytoskeletal alignment induced by the applied strain. This prediction agrees with experimental observations of epithelial response in lithographically patterned micro tissues. 

We use self-consistent field theory to study the isotropic–nematic interface and topological defects in a compressible nematic of semi-flexible molecules. 

We analyze the spontaneous chiral-symmetry breaking states of a nematic liquid crystal system confined to a cylindrical capillary with homeotropic boundary conditions. A stability diagram is constructed, and the geometry of the states investigated. 

A path-independent measure in order parameter space is introduced such that, when integrated along any closed contour in a three-dimensional nematic phase, it yields the topological charge of any line defects encircled by the contour. A related measure, when integrated over either closed or open surfaces, reduces to known results for the charge associated with point defects (hedgehogs) or Skyrmions. We further define a tensor density, the disclination density tensor $\mathbf{D}$, from which the location of a disclination line can be determined. This tensor density has a dyadic decomposition near the line into its tangent and its rotation vector, allowing a convenient determination of both. The tensor $\mathbf{D}$may be non-zero in special configurations in which there are no defects (double-splay or double-twist configurations), and its behaviour there is provided. The special cases of Skyrmions and hedgehog defects are also examined, including the computation of their topological charge from $\mathbf{D}$. 

The structure of isolated disclinations and disclination dipoles in anisotropically elastic nematic liquid crystals is exploredviaa singular potential computational model.