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Abstract ObjectiveThe use of electronic health records (EHRs) for clinical risk prediction is on the rise. However, in many practical settings, the limited availability of task-specific EHR data can restrict the application of standard machine learning pipelines. In this study, we investigate the potential of leveraging language models (LMs) as a means to incorporate supplementary domain knowledge for improving the performance of various EHR-based risk prediction tasks. MethodsWe propose two novel LM-based methods, namely “LLaMA2-EHR” and “Sent-e-Med.” Our focus is on utilizing the textual descriptions within structured EHRs to make risk predictions about future diagnoses. We conduct a comprehensive comparison with previous approaches across various data types and sizes. ResultsExperiments across 6 different methods and 3 separate risk prediction tasks reveal that employing LMs to represent structured EHRs, such as diagnostic histories, results in significant performance improvements when evaluated using standard metrics such as area under the receiver operating characteristic (ROC) curve and precision-recall (PR) curve. Additionally, they offer benefits such as few-shot learning, the ability to handle previously unseen medical concepts, and adaptability to various medical vocabularies. However, it is noteworthy that outcomes may exhibit sensitivity to a specific prompt. ConclusionLMs encompass extensive embedded knowledge, making them valuable for the analysis of EHRs in the context of risk prediction. Nevertheless, it is important to exercise caution in their application, as ongoing safety concerns related to LMs persist and require continuous consideration. 

Misinformation regarding climate change is a key roadblock in addressing one of the most serious threats to humanity. This paper investigates factual accuracy in large language models (LLMs) regarding climate information. Using true/false labeled Q&A data for fine-tuning and evaluating LLMs on climate-related claims, we compare open-source models, assessing their ability to generate truthful responses to climate change questions. We investigate the detectability of models intentionally poisoned with false climate information, finding that such poisoning may not affect the accuracy of a model’s responses in other domains. Furthermore, we compare the effectiveness of unlearning algorithms, fine-tuning, and Retrieval-Augmented Generation (RAG) for factually grounding LLMs on climate change topics. Our evaluation reveals that unlearning algorithms can be effective for nuanced conceptual claims, despite previous findings suggesting their inefficacy in privacy contexts. These insights aim to guide the development of more factually reliable LLMs and highlight the need for additional work to secure LLMs against misinformation attacks.