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Inhibition of glycoprotein biosynthesis in the pathogenic bacterium Helicobacter pylori by masked carbohydrate phosphonates

https://doi.org/10.1039/D5CC05452D

Soleimani, Ebrahim; Chowdhury, Aniqa; Zhu, Jian-She; Ospanow, Elisa; Moulton, Karen D; Dube, Danielle H; Jakeman, David L (January 2026, Chemical Communications)

A masked bis(pivaloyloxymethyl) phosphonate analogue of α-d-glucose 1-phosphate demonstrates significant glycoprotein biosynthesis inhibition inHelicobacter pyloriusing metabolic oligosaccharide engineering.
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Free, publicly-accessible full text available January 8, 2027
Examination of Acetylated Monosaccharides as Metabolic Probes in Bacteria

https://doi.org/10.1021/acsinfecdis.5c00765

Nigrovic, Sophia_E; Paul, Ankita; Maji, Soumyakanta; Ghosh, Antara; Tran, Jack; Luong, Phuong; Rackear, William_J; Stemmler, Elizabeth_A; Moulton, Karen_D; Kulkarni, Suvarn_S; et al (October 2025, ACS Infectious Diseases)
Chemical biology tools to probe bacterial glycans

https://doi.org/10.1016/j.cbpa.2024.102453

Calles-Garcia, Daniel; Dube, Danielle H (June 2024, Current Opinion in Chemical Biology)
Wu, Peng; Huang, Mia (Ed.)
Bacterial cells are covered by a complex carbohydrate coat of armor that allows bacteria to thrive in a range of environments. As a testament to the importance of bacterial glycans, effective and heavily utilized antibiotics including penicillin and vancomycin target and disrupt the bacterial glycocalyx. Despite their importance, the study of bacterial glycans lags far behind their eukaryotic counterparts. Bacterial cells use a large palette of monosaccharides to craft glycans, leading to molecules that are significantly more complex than eukaryotic glycans and that are refractory to study. Fortunately, chemical tools designed to probe bacterial glycans have yielded insights into these molecules, their structures, their biosynthesis, and their functions.
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