Search for: All records

This paper studies the data-driven reconstruction of firing rate dynamics of brain activity described by linear-threshold network models. Identifying the system parameters directly leads to a large number of variables and a highly non-convex objective function. Instead, our approach introduces a novel reformulation that incorporates biological organizational features and turns the identification problem into a scalar variable optimization of a discontinuous, non-convex objective function. We prove that the minimizer of the objective function is unique and establish that the solution of the optimization problem leads to the identification of all the desired system parameters. These results are the basis to introduce an algorithm to find the optimizer by searching the different regions corresponding to the domain of definition of the objective function. To deal with measurement noise in sampled data, we propose a modification of the original algorithm whose identification error is linearly bounded by the magnitude of the measurement noise. We demonstrate the effectiveness of the proposed algorithms through simulations on synthetic and experimental data. 

Learning is a key function in the brain to be able to achieve the activity patterns required to perform various activities. While specific behaviors are determined by activity in localized regions, the interconnections throughout the entire brain play a key role in enabling its ability to exhibit desired activity. To mimic this setup, this paper examines the use of reservoir computing to control a linear-threshold network brain model to a desired trajectory. We first formally design open- and closed-loop controllers that achieve reference tracking under suitable conditions on the synaptic connectivity. Given the impracticality of evaluating closed-form control signals, particularly with growing network complexity, we provide a framework where a reservoir of a larger size than the network is trained to drive the activity to the desired pattern. We illustrate the versatility of this setup in two applications: selective recruitment and inhibition of neuronal populations for goal-driven selective attention, and network intervention for the prevention of epileptic seizures.