Search for: All records

Semantic segmentation of medical images is pivotal in applications like disease diagnosis and treatment planning. While deep learning automates this task effectively, it struggles in ultra low-data regimes for the scarcity of annotated segmentation masks. To address this, we propose a generative deep learning framework that produces high-quality image-mask pairs as auxiliary training data. Unlike traditional generative models that separate data generation from model training, ours uses multi-level optimization for end-to-end data generation. This allows segmentation performance to guide the generation process, producing data tailored to improve segmentation outcomes. Our method demonstrates strong generalization across 11 medical image segmentation tasks and 19 datasets, covering various diseases, organs, and modalities. It improves performance by 10–20% (absolute) in both same- and out-of-domain settings and requires 8–20 times less training data than existing approaches. This greatly enhances the feasibility and cost-effectiveness of deep learning in data-limited medical imaging scenarios. 

Large-scale general domain pretraining followed by downstream-specific finetuning has become a predominant paradigm in machine learning. However, discrepancies between the pretraining and target domains can still lead to performance degradation in certain cases, underscoring the need for task-adaptive continued pretraining (TAP). TAP methods typically involve continued pretraining on task-specific unlabeled datasets or introducing additional unsupervised learning objectives to enhance model capabilities. While many TAP methods perform continued pretraining with multiple pretraining objectives, they often determine the tradeoff parameters between objectives manually, resulting in suboptimal outcomes and higher computational costs. In this paper, we propose TapWeight, a task-adaptive pretraining framework which automatically determines the optimal importance of each pretraining objective based on downstream feedback. TapWeight reweights each pretraining objective by solving a multi-level optimization problem. We applied TapWeight to both molecular property prediction and natural language processing tasks, significantly surpassing baseline methods. Experimental results validate the effectiveness and generalizability of TapWeight. 

Masked Autoencoder (MAE) is a notable method for self-supervised pretraining in visual representation learning. It operates by randomly masking image patches and reconstructing these masked patches using the unmasked ones. A key limitation of MAE lies in its disregard for the varying informativeness of different patches, as it uniformly selects patches to mask. To overcome this, some approaches propose masking based on patch informativeness. However, these methods often do not consider the specific requirements of downstream tasks, potentially leading to suboptimal representations for these tasks. In response, we introduce the Multi-level Optimized Mask Autoencoder (MLO-MAE), a novel framework that leverages end-to-end feedback from downstream tasks to learn an optimal masking strategy during pretraining. Our experimental findings highlight MLO-MAE's significant advancements in visual representation learning. Compared to existing methods, it demonstrates remarkable improvements across diverse datasets and tasks, showcasing its adaptability and efficiency. Our code is available at https://github.com/Alexiland/MLO-MAE 

Bi-level optimization methods in machine learning are popularly effective in subdomains of neural architecture search, data reweighting, etc. However, most of these methods do not factor in variations in learning difficulty, which limits their performance in real-world applications. To address the above problems, we propose a framework that imitates the learning process of humans. In human learning, learners usually focus more on the topics where mistakes have been made in the past to deepen their understanding and master the knowledge. Inspired by this effective human learning technique, we propose a multilevel optimization framework, learning from mistakes (LFM), for machine learning. We formulate LFM as a three-stage optimization problem: 1) the learner learns, 2) the learner relearns based on the mistakes made before, and 3) the learner validates his learning. We develop an efficient algorithm to solve the optimization problem. We further apply our method to differentiable neural architecture search and data reweighting. Extensive experiments on CIFAR-10, CIFAR-100, ImageNet, and other related datasets powerfully demonstrate the effectiveness of our approach. The code of LFM is available at: https://github.com/importZL/LFM. 

Interest in automatically searching for Transformer neural architectures for machine translation (MT) has been increasing. Current methods show promising results in in-domain settings, where training and test data share the same distribution. However, in real-world MT applications, it is common that the test data has a different distribution than the training data. In these out-of-domain (OOD) situations, Transformer architectures optimized for the linguistic characteristics of the training sentences struggle to produce accurate translations for OOD sentences during testing. To tackle this issue, we propose a multi-level optimization based method to automatically search for neural architectures that possess robust OOD generalization capabilities. During the architecture search process, our method automatically synthesizes approximated OOD MT data, which is used to evaluate and improve the architectures' ability of generalizing to OOD scenarios. The generation of approximated OOD data and the search for optimal architectures are executed in an integrated, end-to-end manner. Evaluated across multiple datasets, our method demonstrates strong OOD generalization performance, surpassing state-of-the-art approaches.