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Abstract Let $$E$$ be an elliptic curve defined over $${\mathbb{Q}}$$ of conductor $$N$$, $$p$$ an odd prime of good ordinary reduction such that $E[p]$ is an irreducible Galois module, and $$K$$ an imaginary quadratic field with all primes dividing $Np$ split. We prove Iwasawa main conjectures for the $${\mathbb{Z}}_{p}$$-cyclotomic and $${\mathbb{Z}}_{p}$$-anticyclotomic deformations of $$E$$ over $${\mathbb{Q}}$$ and $K,$ respectively, dispensing with any of the ramification hypotheses on $E[p]$ in previous works. The strategy employs base change and the two-variable zeta element associated to $$E$$ over $$K$$, via which the sought after main conjectures are deduced from Wan’s divisibility towards a three-variable main conjecture for $$E$$ over a quartic CM field containing $$K$$ and certain Euler system divisibilities. As an application, we prove cases of the two-variable main conjecture for $$E$$ over $$K$$. The aforementioned one-variable main conjectures imply the $$p$$-part of the conjectural Birch and Swinnerton-Dyer formula for $$E$$ if $$\operatorname{ord}_{s=1}L(E,s)\leq 1$$. They are also an ingredient in the proof of Kolyvagin’s conjecture and its cyclotomic variant in our joint work with Grossi [1].