Search for: All records

Grid cells play a principal role in enabling cognitive representations of ambient environments. The key property of these cells—the regular arrangement of their firing fields—is commonly viewed as a means for establishing spatial scales or encoding specific locations. However, using grid cells’ spiking outputs for deducing geometric orderliness proves to be a strenuous task due to fairly irregular activation patterns triggered by the animal’s sporadic visits to the grid fields. This article addresses statistical mechanisms enabling emergent regularity of grid cell firing activity from the perspective of percolation theory. Using percolation phenomena for modeling the effect of the rat’s moves through the lattices of firing fields sheds new light on the mechanisms of spatial information processing, spatial learning, path integration, and establishing spatial metrics. It is also shown that physiological parameters required for spiking percolation match the experimental range, including the characteristic 2/3 ratio between the grid fields’ size and the grid spacing, pointing at a biological viability of the approach.

Topological data analyses are widely used for describing and conceptualizing large volumes of neurobiological data, e.g., for quantifying spiking outputs of large neuronal ensembles and thus understanding the functions of the corresponding networks. Below we discuss an approach in which convergent topological analyses produce insights into how information may be processed in mammalian hippocampus—a brain part that plays a key role in learning and memory. The resulting functional model provides a unifying framework for integrating spiking data at different timescales and following the course of spatial learning at different levels of spatiotemporal granularity. This approach allows accounting for contributions from various physiological phenomena into spatial cognition—the neuronal spiking statistics, the effects of spiking synchronization by different brain waves, the roles played by synaptic efficacies and so forth. In particular, it is possible to demonstrate that networks with plastic and transient synaptic architectures can encode stable cognitive maps, revealing the characteristic timescales of memory processing.