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   https://doi.org/10.1002/aic.16844  

   Ansari, Ali ; Schultheis, Kinsey ; Patel, Reema ; Al‐Qadi, Kareem I. ; Chen, Si ; Jensen, Cassandra R. ; Schad, Samantha R. ; Weddell, Jared C. ; Vanka, Surya P. ; Imoukhuede, P. I. ( November 2019 , AIChE Journal)

   Precision medicine requires high throughput cell isolation and measurement that maintains physiology. Unfortunately, many techniques are slow or alter cell biomarkers cells. This necessitates new approaches, which we achieve by integrating affinity‐based cell isolation with spiral microfluidics. We characterize the device via computational simulations, predicting wall shear stress within an order of magnitude of arterial wall shear stress (~0.2 Pa). We identify that poly‐l‐lysine supplementation preserves cell geometry and improves cell release. We demonstrate preservation of angiogenic biomarker concentrations, measuring 1,000–2,000 vascular endothelial growth factor receptor‐1 per human umbilical vein endothelial cell, which is in line with the previously reported measurements. We attain 76.7 ± 9.0% release of captured cells by integrating thermophoresis and optimizing buffer residence time. Ultimately, we find that combining affinity‐based cell isolation (secondary anchor targeted cell release) with spiral microfluidics offers a fast, biomarker preserving approach needed to individualize medicine.

    

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2. Large DNA Methylation Nadirs Anchor Chromatin Loops Maintaining Hematopoietic Stem Cell Identity

   https://doi.org/10.1016/j.molcel.2020.04.018  

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3. Integrated nanotechnology platform for tumor-targeted multimodal imaging and therapeutic cargo release

   https://doi.org/10.1073/pnas.1525796113  

   Hosoya, Hitomi ; Dobroff, Andrey S. ; Driessen, Wouter H. ; Cristini, Vittorio ; Brinker, Lina M. ; Staquicini, Fernanda I. ; Cardó-Vila, Marina ; D’Angelo, Sara ; Ferrara, Fortunato ; Proneth, Bettina ; et al ( February 2016 , Proceedings of the National Academy of Sciences)
4. Noninvasive Targeted Transcranial Neuromodulation via Focused Ultrasound Gated Drug Release from Nanoemulsions

   https://doi.org/10.1021/acs.nanolett.6b03517  

   Airan, Raag D. ; Meyer, Randall A. ; Ellens, Nicholas P. ; Rhodes, Kelly R. ; Farahani, Keyvan ; Pomper, Martin G. ; Kadam, Shilpa D. ; Green, Jordan J. ( February 2017 , Nano Letters)
5. Understanding the Mechanism of Secondary Cation Release from the (001) Surface of Li(Ni 1/3 Mn 1/3 Co 1/3 )O 2 : Insights from First-Principles

   https://doi.org/10.1021/acs.jpcc.3c02764  

   Hudson, Blake G. ; Jones, Diamond T. ; Rivera Bustillo, Victoria M. ; Bennett, Joseph W. ; Mason, Sara E. ( October 2023 , The Journal of Physical Chemistry C)

   The transformations of complex metal oxides in aqueous settings must be studied to form a chemical understanding of how technologically relevant nanomaterials impact the environment upon disposal. Owing to the inherent heterogeneity and structural complexity of the ternary intercalation material Li(NixMnyCo1-x-y)O2 (NMC), the mechanisms of chemical processes at the solid–water interface are challenging to model. Here, density functional theory (DFT) + solvent ion methodology is used to study the energetics of stepwise release of two surface metals following unique pathways. The study spans different combinations of metal removal and also considers unique patterns of defects formed by modeling the NMC surface in supercells. The approach here also considers the equilibration of the surface with the surroundings between successive metal removals. A key finding is that a second metal removal prefers to proceed at a metal lattice site adjacent to the initial defect, and this is attributed in part to how the resulting slab with two metal vacancies maintains the most antiferromagnetic couplings between the remaining Ni/Mn. 

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