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Title: Towards Reproducible Disease Models using the Systems Biology Markup Language
Disease modelers have been modeling progression of diseases for several decades using tools such as Markov Models or microsimulation. However, they need to address a serious challenge; many models they create are not reproducible. Moreover, there is no proper practice that ensures reproducible models, since modelers rely on loose guidelines that change periodically, rather than well-defined machine-readable standards. The Systems Biology Markup Language (SBML) is one such standard that allows exchange of models amongst different software tools. Recently, the SBML Arrays package has been developed, which extends the standard to allow handling simulation of populations. This paper demonstrates through several abstract examples how microsimulation disease models can be encoded using the SBML Arrays package enabling reproducible disease modeling.  more » « less
Award ID(s):
1748200 1218095
PAR ID:
10065226
Author(s) / Creator(s):
; ;
Date Published:
Journal Name:
Simulation
ISSN:
0037-5497
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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