Here, we present a rapidly prototyped, cost-efficient, and 3D printed quasi-optical sample holder for improving the signal-to-noise ratio (SNR) in modern, resonator-free, and high-field electron paramagnetic resonance (HFEPR) spectrometers. Such spectrometers typically operate in induction mode: The detected EPR (“cross-polar”) signal is polarized orthogonal to the incident (“co-polar”) radiation. The sample holder makes use of an adjustable sample positioner that allows for optimizing the sample position to maximize the 240-gigahertz magnetic fieldB1and a rooftop mirror that allows for small rotations of the microwave polarization to maximize the cross-polar signal and minimize the co-polar background. When optimally tuned, the sample holder was able to improve co-polar isolation by ≳20 decibels, which is proven beneficial for maximizing the SNR in rapid-scan, pulsed, and continuous-wave EPR experiments. In rapid-scan mode, the improved SNR enabled the recording of entire EPR spectra of a narrow-line radical in millisecond time scales, which, in turn, enabled real-time monitoring of a sample’s evolving line shape.
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Terahertz Polarimetric Imaging for Biomedical Applications
We present a reflection-mode, polarimetric imaging system that can achieve 45µm sample resolution and measure the co-polarized and cross-polarized reflected field components individually over the 750GHz1.1THz band. The system is based on a vector network analyzer (VNA) in conjunction with frequency extenders and illuminates the sample under test through a high-resistivity Silicon (HRSi) lens to achieve image resolution 3.42-times better than the free-space diffraction limit. The two ports of the VNA are used to capture the co-polarized and cross-polarized images of the same sample. A simple quasi-optical setup is used to isolate and direct the cross-polarized reflected signal without significantly degrading the copolarized signal. The utility of the proposed system is demonstrated using biomedical samples in form of formalin-fixed paraffin-embedded (FFPE) tissues.
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- Award ID(s):
- 1710977
- PAR ID:
- 10066674
- Date Published:
- Journal Name:
- 2018 IEEE Antennas and Propagation Society Symposium on Antenna and Propagation and URSI CNC/USNC Joint Meeting
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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