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Abstract Functional regulation of cell signaling through dynamic changes in protein activity state as well as spatial organization represent two dynamic, complex, and conserved phenomena in biology. Seemingly separate areas of ‐omics method development have focused on building tools that can detect and quantify protein activity states, as well as map sub‐cellular and intercellular protein organization. Integration of these efforts, through the development of chemical tools and platforms that enable detection and quantification of protein functional states with spatial resolution provide opportunities to better understand heterogeneity in the proteome within cell organelles, multi‐cellular tissues, and whole organisms. This review provides an overview of and considerations for major classes of chemical proteomic probes and technologies that enable protein activity mapping from sub‐cellular compartments to live animals.
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Highlights in Chemical Glycobiology
Abstract The advances of chemical biology have provided means for a better understanding of complex biological systems at the molecular level as well as solutions to the problems associated with the complex systems. The interdisciplinary approach of chemical biology was also embraced by the research in glycoscience as illustrated in this essay with some of the relevant examples from our group.
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- Award ID(s):
- 1664283
- PAR ID:
- 10080549
- Publisher / Repository:
- Wiley Blackwell (John Wiley & Sons)
- Date Published:
- Journal Name:
- Israel Journal of Chemistry
- Volume:
- 59
- Issue:
- 1-2
- ISSN:
- 0021-2148
- Page Range / eLocation ID:
- p. 18-22
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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