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Award ID contains: 1664283

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  1. ; (, Israel Journal of Chemistry)
    Abstract The advances of chemical biology have provided means for a better understanding of complex biological systems at the molecular level as well as solutions to the problems associated with the complex systems. The interdisciplinary approach of chemical biology was also embraced by the research in glycoscience as illustrated in this essay with some of the relevant examples from our group. 
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  2. ; ; (, Organic Letters)
    The clinically approved Fondaparinux (Arixtra) has been used for the treatment of deep vein thrombosis and acute pulmonary embolism since 2002 and is considered to be better than the low-molecular weight heparin in terms of anticoagulation response, duration of action, and biosafety. However, the synthetic methods previously developed for its manufacture are relatively complicated, thus restricting its extensive use. We report here a potentially scalable and programmable one-pot synthesis of Fondaparinux using the [1,2,2] strategy and designed thioglycosides with well-defined reactivity as building blocks. 
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  3. ; ; ; ; ; ; ; ; (, Journal of the American Chemical Society)
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  4. ; (, Journal of the American Chemical Society)
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  5. ; (, Chemical Science)
    We report the design of building blocks with optimized reactivities for the programmable one-pot synthesis of heparin pentasaccharides with regiodefined sulfation patterns. 
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