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Title: Antibacterial Activity of Polymers: Discussions on the Nature of Amphiphilic Balance
Abstract The purpose of this Viewpoint is to discuss the molecular design principles that guide development of synthetic antimicrobial polymers, especially those intended to mimic the structure of host defense peptides (HDPs). In particular, we focus on the principle of “amphiphilic balance” as it relates to some recently developed polyphosphoniums with somewhat atypical structure. We find that the fundamental concept of amphiphilic balance is still applicable to these new polymers, but that the method to achieve such balance is somewhat unique. We then briefly outline the future challenges and opportunities in this field.  more » « less
Award ID(s):
1653418
PAR ID:
10085906
Author(s) / Creator(s):
 ;  ;  ;  
Publisher / Repository:
Wiley Blackwell (John Wiley & Sons)
Date Published:
Journal Name:
Angewandte Chemie
Volume:
131
Issue:
12
ISSN:
0044-8249
Page Range / eLocation ID:
p. 3728-3731
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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