skip to main content
US FlagAn official website of the United States government
dot gov icon
Official websites use .gov
A .gov website belongs to an official government organization in the United States.
https lock icon
Secure .gov websites use HTTPS
A lock ( lock ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.


Title: Sequence and Nuclease Requirements for Breakage and Healing of a Structure-Forming (AT)n Sequence within Fragile Site FRA16D
Award ID(s):
1817499
PAR ID:
10107448
Author(s) / Creator(s):
; ; ; ; ; ; ; ; ; ; ;
Date Published:
Journal Name:
Cell Reports
Volume:
27
Issue:
4
ISSN:
2211-1247
Page Range / eLocation ID:
1151 to 1164.e5
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
More Like this
  1. null (Ed.)
    Speech recognition and machine translation have made major progress over the past decades, providing practical systems to map one language sequence to another. Although multiple modalities such as sound and video are becoming increasingly available, the state-of-the-art systems are inherently unimodal, in the sense that they take a single modality --- either speech or text --- as input. Evidence from human learning suggests that additional modalities can provide disambiguating signals crucial for many language tasks. Here, we describe the dataset, a large, open-domain collection of videos with transcriptions and their translations. We then show how this single dataset can be used to develop systems for a variety of language tasks and present a number of models meant as starting points. Across tasks, we find that building multi-modal architectures that perform better than their unimodal counterpart remains a challenge. This leaves plenty of room for the exploration of more advanced solutions that fully exploit the multi-modal nature of the dataset, and the general direction of multimodal learning with other datasets as well. 
    more » « less
  2. null (Ed.)
  3. In recent times, sequence-to-sequence (seq2seq) models have gained a lot of popularity and provide stateof-the-art performance in a wide variety of tasks, such as machine translation, headline generation, text summarization, speech-to-text conversion, and image caption generation. The underlying framework for all these models is usually a deep neural network comprising an encoder and a decoder. Although simple encoder–decoder models produce competitive results, many researchers have proposed additional improvements over these seq2seq models, e.g., using an attention-based model over the input, pointer-generation models, and self-attention models. However, such seq2seq models suffer from two common problems: 1) exposure bias and 2) inconsistency between train/test measurement. Recently, a completely novel point of view has emerged in addressing these two problems in seq2seq models, leveraging methods from reinforcement learning (RL). In this survey, we consider seq2seq problems from the RL point of view and provide a formulation combining the power of RL methods in decision-making with seq2seq models that enable remembering long-term memories. We present some of the most recent frameworks that combine the concepts from RL and deep neural networks. Our work aims to provide insights into some of the problems that inherently arise with current approaches and how we can address them with better RL models. We also provide the source code for implementing most of the RL models discussed in this paper to support the complex task of abstractive text summarization and provide some targeted experiments for these RL models, both in terms of performance and training time. 
    more » « less
  4. Supramolecular polymer networks exhibit unique and tunable thermodynamic and dynamic properties that are attractive for a wide array of applications, such as adhesives, rheology modifiers, and compatibilizers. Coherent states (CS) field theories have emerged as a powerful approach for describing the possibly infinite reaction products that result from associating polymers. Up to this point, CS theories have focused on relatively simple polymer architectures. In this work, we develop an extension of the CS framework to study polymers with reversible bonds distributed along the polymer backbone, opening a broad array of new materials that can be studied with theoretical methods. We use this framework to discern the role of reactive site placement on sol–gel phase behavior, including the prediction of a microstructured gel phase that has not been reported for neutral polymer gels. Our results highlight the subtleties of thermodynamics in supramolecular polymers and the necessity for theories that capture them. 
    more » « less