skip to main content
US FlagAn official website of the United States government
dot gov icon
Official websites use .gov
A .gov website belongs to an official government organization in the United States.
https lock icon
Secure .gov websites use HTTPS
A lock ( lock ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.


Title: Quasi-Newton Stochastic Optimization Algorithm for Parameter Estimation of a Stochastic Model of the Budding Yeast Cell Cycle
Award ID(s):
1565314 1838271
PAR ID:
10111392
Author(s) / Creator(s):
; ; ; ; ; ; ; ;
Date Published:
Journal Name:
IEEE/ACM Transactions on Computational Biology and Bioinformatics
Volume:
16
Issue:
1
ISSN:
1545-5963
Page Range / eLocation ID:
301 to 311
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
More Like this
  1. We consider particles obeying Langevin dynamics while being at known positions and having known velocities at the two end-points of a given interval. Their motion in phase space can be modeled as an Ornstein–Uhlenbeck process conditioned at the two end-points—a generalization of the Brownian bridge. Using standard ideas from stochastic optimal control we construct a stochastic differential equation (SDE) that generates such a bridge that agrees with the statistics of the conditioned process, as a degenerate diffusion. Higher order linear diffusions are also considered. In general, a time-varying drift is sufficient to modify the prior SDE and meet the end-point conditions. When the drift is obtained by solving a suitable differential Lyapunov equation, the SDE models correctly the statistics of the bridge. These types of models are relevant in controlling and modeling distribution of particles and the interpolation of density functions. 
    more » « less