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Abstract The goal of classifying shock metamorphic features in meteorites is to estimate the corresponding shock pressure conditions. However, the temperature variability of shock metamorphism is equally important and can result in a diverse and heterogeneous set of shock features in samples with a common overall shock pressure. In particular, high-pressure (HP) minerals, which were previously used as a solid indicator of high shock pressure in meteorites, require complex pressure–temperature–time (
P–T–t ) histories to form and survive. First, parts of the sample must be heated to melting temperatures, at high pressure, to enable rapid formation of HP minerals before pressure release. Second, the HP minerals must be rapidly cooled to below a critical temperature, before the pressure returns to ambient conditions, to avoid retrograde transformation to their low-pressure polymorphs. These two constraints require the sample to contain large temperature heterogeneities, e.g. melt veins in a cooler groundmass, during shock. In this study, we calculated shock temperatures and possibleP–T paths of chondritic and differentiated mafic–ultramafic rocks for various shock pressures. TheseP–T conditions and paths, combined with observations from shocked meteorites, are used to constrain shock conditions andP–T –t histories of HP-mineral bearing samples. The need for rapid thermal quench of HP phases requires a relatively lowmore » -
Abstract Septic shock is a life-threatening condition in which timely treatment substantially reduces mortality. Reliable identification of patients with sepsis who are at elevated risk of developing septic shock therefore has the potential to save lives by opening an early window of intervention. We hypothesize the existence of a novel clinical state of sepsis referred to as the “pre-shock” state, and that patients with sepsis who enter this state are highly likely to develop septic shock at some future time. We apply three different machine learning techniques to the electronic health record data of 15,930 patients in the MIMIC-III database to test this hypothesis. This novel paradigm yields improved performance in identifying patients with sepsis who will progress to septic shock, as defined by Sepsis- 3 criteria, with the best method achieving a 0.93 area under the receiver operating curve, 88% sensitivity, 84% specificity, and median early warning time of 7 hours. Additionally, we introduce the notion of patient-specific positive predictive value, assigning confidence to individual predictions, and achieving values as high as 91%. This study demonstrates that early prediction of impending septic shock, and thus early intervention, is possible many hours in advance.