Abstract LetXbe a compact normal complex space of dimensionnandLbe a holomorphic line bundle onX. Suppose that$$\Sigma =(\Sigma _1,\ldots ,\Sigma _\ell )$$ is an$$\ell $$ -tuple of distinct irreducible proper analytic subsets ofX,$$\tau =(\tau _1,\ldots ,\tau _\ell )$$ is an$$\ell $$ -tuple of positive real numbers, and let$$H^0_0(X,L^p)$$ be the space of holomorphic sections of$$L^p:=L^{\otimes p}$$ that vanish to order at least$$\tau _jp$$ along$$\Sigma _j$$ ,$$1\le j\le \ell $$ . If$$Y\subset X$$ is an irreducible analytic subset of dimensionm, we consider the space$$H^0_0 (X|Y, L^p)$$ of holomorphic sections of$$L^p|_Y$$ that extend to global holomorphic sections in$$H^0_0(X,L^p)$$ . Assuming that the triplet$$(L,\Sigma ,\tau )$$ is big in the sense that$$\dim H^0_0(X,L^p)\sim p^n$$ , we give a general condition onYto ensure that$$\dim H^0_0(X|Y,L^p)\sim p^m$$ . WhenLis endowed with a continuous Hermitian metric, we show that the Fubini-Study currents of the spaces$$H^0_0(X|Y,L^p)$$ converge to a certain equilibrium current onY. We apply this to the study of the equidistribution of zeros inYof random holomorphic sections in$$H^0_0(X|Y,L^p)$$ as$$p\rightarrow \infty $$ .
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Zero-field nuclear magnetic resonance of chemically exchanging systems
Abstract Zero- to ultralow-field (ZULF) nuclear magnetic resonance (NMR) is an emerging tool for precision chemical analysis. In this work, we study dynamic processes and investigate the influence of chemical exchange on ZULF NMRJ-spectra. We develop a computational approach that allows quantitative calculation ofJ-spectra in the presence of chemical exchange and apply it to study aqueous solutions of [15N]ammonium (15N$${\mathrm{H}}_4^ +$$ ) as a model system. We show that pH-dependent chemical exchange substantially affects theJ-spectra and, in some cases, can lead to degradation and complete disappearance of the spectral features. To demonstrate potential applications of ZULF NMR for chemistry and biomedicine, we show a ZULF NMR spectrum of [2-13C]pyruvic acid hyperpolarized via dissolution dynamic nuclear polarization (dDNP). We foresee applications of affordable and scalable ZULF NMR coupled with hyperpolarization to study chemical exchange phenomena in vivo and in situations where high-field NMR detection is not possible to implement.
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- Award ID(s):
- 1709944
- PAR ID:
- 10153432
- Publisher / Repository:
- Nature Publishing Group
- Date Published:
- Journal Name:
- Nature Communications
- Volume:
- 10
- Issue:
- 1
- ISSN:
- 2041-1723
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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