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Title: Recent developments in nickel-catalyzed intermolecular dicarbofunctionalization of alkenes
Nickel-catalyzed three-component alkene difunctionalization has rapidly emerged as a powerful tool for forging two C–C bonds in a single reaction. Building upon the powerful modes of bond construction in traditional two-component cross-coupling, various research groups have demonstrated the versatility of nickel in enabling catalytic 1,2-dicarbofunctionalization using a wide range of carbon-based electrophiles and nucleophiles and in a fully intermolecular fashion. Though this area has emerged only recently, the last few years have witnessed a proliferation of publications on this topic, underscoring the potential of this strategy to develop into a general platform that offers high regio- and stereoselectivity. This minireview highlights the recent progress in the area of intermolecular 1,2-dicarbofunctionalization of alkenes via nickel catalysis and discusses lingering challenges within this reactivity paradigm.  more » « less
Award ID(s):
1800280
PAR ID:
10158990
Author(s) / Creator(s):
; ; ; ;
Date Published:
Journal Name:
Chemical Science
Volume:
11
Issue:
17
ISSN:
2041-6520
Page Range / eLocation ID:
4287 to 4296
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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