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Title: Ni- and Pd-Catalyzed Enantioselective 1,2-Dicarbofunctionalization of Alkenes
Abstract

Catalytic enantioselective 1,2-dicarbofunctionalization (1,2-DCF) of alkenes is a powerful transformation of growing importance in organic synthesis for constructing chiral building blocks, bioactive molecules, and agrochemicals. Both in a two- and three-component context, this family of reactions generates densely functionalized, structurally complex products in a single step. Across several distinct mechanistic pathways at play in these transformations with nickel or palladium catalysts, stereocontrol can be obtained through tailored chiral ligands. In this Review we discuss the various strategies, mechanisms, and catalysts that have been applied to achieve enantioinduction in alkene 1,2-DCF.

1 Introduction

2 Two-Component Enantioselective 1,2-DCF via Migratory Insertion

3 Two-Component Enantioselective 1,2-DCF via Radical Capture

4 Three-Component Enantioselective 1,2-DCF via Radical Capture

5 Three-Component Enantioselective 1,2-DCF via Migratory Insertion

6 Miscellaneous Mechanisms

7 Conclusion

 
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Award ID(s):
2102550
NSF-PAR ID:
10512101
Author(s) / Creator(s):
; ;
Publisher / Repository:
Thieme
Date Published:
Journal Name:
Synthesis
Volume:
56
Issue:
01
ISSN:
0039-7881
Page Range / eLocation ID:
1 to 15
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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