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1. Determining Michael acceptor reactivity from kinetic, mechanistic, and computational analysis for the base-catalyzed thiol-Michael reaction

   https://doi.org/10.1039/d1py00363a  

   Huang, Sijia ; Kim, Kangmin ; Musgrave, Grant M. ; Sharp, Marcus ; Sinha, Jasmine ; Stansbury, Jeffrey W. ; Musgrave, Charles B. ; Bowman, Christopher N. ( June 2021 , Polymer Chemistry)

   A combined experimental and computational study of the reactivities of seven commonly used Michael acceptors paired with two thiols within the framework of photobase-catalyzed thiol-Michael reactions is reported. The rate coefficients of the propagation ( k P ), reverse propagation ( k -P ), chain-transfer ( k CT ), and overall reaction ( k overall ) were experimentally determined and compared with the well-accepted electrophilicity parameters of Mayr and Parr, and DFT-calculated energetics. Both Mayr's and Parr's electrophilicity parameters predict the reactivities of these structurally varying vinyl functional groups well, covering a range of overall reaction rate coefficients from 0.5 to 6.2 s −1 . To gain insight into the individual steps, the relative energies have been calculated using DFT for each of the stationary points along this step-growth reaction between ethanethiol and the seven alkenes. The free energies of the individual steps reveal the underlying factors that control the reaction barriers for propagation and chain transfer. Both the propagation and chain transfer steps are under kinetic control. These results serve as a useful guide for Michael acceptor selection to design and predict thiol-Michael-based materials with appropriate kinetic and material properties.
2. Multicomponent, Enantioselective Michael–Michael-Aldol-β-Lactonizations Delivering Complex β-Lactones

   https://doi.org/10.1021/acs.joc.7b02543  

   Van, Khoi N. ; Romo, Daniel ( January 2018 , The Journal of Organic Chemistry)
3. Domino Michael/Michael reaction catalyzed by switchable modularly designed organocatalysts

   https://doi.org/10.1039/D1OB01991K  

   Parella, Ramarao ; Jakkampudi, Satish ; Bora, Pranjal ; Sakkani, Nagaraju ; Zhao, John C.-G. ( December 2021 , Organic & Biomolecular Chemistry)

   The domino Michael/Michael reaction between ( E )-7-aryl-7-oxohept-5-enals and trans -cinnamaldehydes was investigated by using modularly designed organocatalysts (MDOs). It was found that both the enamine and iminium catalytic modes of the MDOs are switchable and can be individually switched on and off by using appropriate combinations of the precatalyst modules and the reaction conditions. When both the enamine and iminium catalysis modes of the MDOs are switched on, the desired domino reaction products can be obtained in good yields and stereoselectivities under optimized conditions.
4. Evaluation of parametric wind models for more accurate modeling of storm surge: a case study of Hurricane Michael

   https://doi.org/10.1007/s11069-021-04525-y  

   Vijayan, Linoj ; Huang, Wenrui ; Yin, Kai ; Ozguven, Eren ; Burns, Simone ; Ghorbanzadeh, Mahyar ( April 2021 , Natural Hazards)
5. A One-Pot Intramolecular Tandem Michael–Aldol Annulation Reaction for the Synthesis of Chiral Pentacyclic Terpenes

   https://doi.org/10.1055/s-0039-1690521  

   Lu, Jianyu ; Koldas, Serkan ; Fan, Huafang ; Desper, John ; Day, Victor W. ; Hua, Duy H. ( October 2019 , Synthesis)

   A chiral tricyclic terpene possessing a 6,6,6-tricyclic framework and a 3,3-dimethyl-7-oxooctylidenyl side chain undergoes a double ring-closing reaction to give two chiral pentacyclic terpenes in a ratio of 4:3 via an intramolecular Michael addition followed by aldol condensation under basic conditions. Three new stereogenic centers are introduced in the initial Michael annulation reaction. Stereoselective installation of an ethoxycarbonyl group at C17 of the two pentacyclic terpenes separately gives the corresponding highly functionalized pentacyclic terpenoids with seven stereogenic centers. The structures and stereochemistry of key intermediates and products are established through X-ray crystallographic analysis. A mechanism is proposed for explaining the stereochemistry in the Michael annulation reaction.