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Title: Enzymatic reaction-based nanopore detection of zinc ions
We report a label-free nanopore sensor for the detection of Zn 2+ ions. By taking advantage of the cleavage of a substrate peptide by zinc-dependent enzymes, nanomolar concentrations of Zn 2+ ions could be detected within minutes. Furthermore, structurally similar transition metals such as Ni 2+ , Co 2+ , Hg 2+ , Cu 2+ , and Cd 2+ did not interfere with their detection. The enzymatic reaction-based nanopore sensing strategy developed in this work may find potential applications in environmental monitoring and medical diagnosis.  more » « less
Award ID(s):
1708596
NSF-PAR ID:
10160772
Author(s) / Creator(s):
; ; ; ;
Date Published:
Journal Name:
The Analyst
Volume:
144
Issue:
24
ISSN:
0003-2654
Page Range / eLocation ID:
7432 to 7436
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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